Abstract: Objective:To study the effect of celery seed extract on the leve of uric acid in rats with hyperuricemia and the control of joint inflammation in gouty arthritis. Methods:Uric acid nephropathy rats models were established by feeding yeast and adenine. Fifty male Wistar rats were divided into five groups including control group,model group and celery seed extrac treatment groups(high-,moderate-and low-doses). The serum uric acid(UA),urea nitrogen(BUN),creatinine(Cr) and activity of liver xanthine oxidase were measured and the pathological changes in renal were detected. The model of acute arthritis was induced by injecting monosodium urate(MSU) into unilateral ankle of rat. Results:The level of serum uric acid of the high-dose treatment group is significantly different from that of the model group(p<0.05). In the high and moderate-dose groups,the activity of the liver xanthine oxidase reduces,but there are no obvious difference between the model group and the two groups(p>0.05). The swelling rate of the high-dose group is obviously lower than that of the model group(p<0.01). The pathological changes in renal of all the treat ment groups are lower than that of the model group. Conclusion:The celery seed extrac has some protective effects on the hyperuricemia and the damage of kidney’function.

Key words: celery seed, gout, hyperuricemia