Abstract: Objective:This study was designed to evaluated the antioxidant effects of SRE on liver and main organs in mice with CCl4-induced acute liver injury. Methodes:The CIR mice were administered by gavage with SRE(100,200 and 400 mg/kg·d,respectively) for 30 days before the administration with a dose ofCCl4(80 mg/kg·d). The mice were sacrificed at 24 h after administration with SRE and their blood,liver,heart,kidney and spleen were collected for assaying antioxidant parameters,respectively. Results:The 400 mg/kg·d dose of SRE significantly(p<0.01) lowers the serum ALT,while the hepatic activities of total SOD,Mn-SOD,Cu,Zn-SOD and GSH-Px are significantly increased(p<0.01),and content of MDA is significantly(p<0.01) lowered when compared with CCl4 administration group. SRE could significantly increase the activities of SOD and GSH-Px in heart and kidney,and lower the content of MDA in heart,compared with CCl4 administration group. The activities of total SOD and Mn-SOD of CCl4 administration group are compensatorily increased in spleen compared with the normal group(p<0.05). After the SRE administration,these indexes are decreased to the normal levels. The component analysis of SRE indicated that polysaccharides and flavonoids may be main antioxidant components. Conclusions:SRE can be proposed to protect the liver and various tissues against CCl4-induced oxidative damage in mice.

Key words: Stropharia rugoso-annulata, extract, acute liver injury, organ, antioxidation