Abstract: Optimizing the formula and technique and using moist pellet manufacturing method, a kind of Gynostemma pentaphyllum buccal tablet without sugar was prepared. The results showed that the concentration of moistening agent and the quantities of several primary materials had great effects on the quality of Gynostemma pentaphyllum buccal tablet. With 70% ethanol as moistening agent, when the formula was 15% Gynostemma pentaphyllum flour, 77% mannitol and 4% aspartame, adding 0.1% mentha-camphor and 3% magnesium stearate of the whole weight of previous materials, new Gynostemma pentaphyllum buccal tablet without sugar could be obtained, with good taste, special flavor of Gynostemma pentaphyllum, smooth surface, identical color, good hardness, good disintegrability and healthy function.

Key words: Gynostemma pentaphyllum, buccal tablet without sugar, technique, quality