Abstract:

A mouse model of diabetes induced by intraperitoneal injection of alloxan was established to investigate the hypoglycemic effect of soluble dietary fiber (SDF) from soybean dregs. Fifty diabetic mice were randomly divided into 5 groups of 10 mice each: high-, medium- and low-dose SDF-treated groups, glibenclamide-treated group and model control group administered with 0.9% saline orally. The levels of blood glucose in all the three SDF-treated groups were obviously decreased and the diabetic symptoms such as weight loss, polydipsia and polyphagia were also relieved, and the best hypoglycemic effect was found in the high-dose group (1000 mg/kg bw). Meanwhile, SDF could improve the glucose tolerance of diabetic mice.

Key words: soluble dietary fiber, diabetes, hypoglycemic effect, glucose tolerance