Effects and Mechanisms of Salvianolic Acid B on Learning Capability and Memory in Aging Mice

doi:10.7506/spkx1002-6630-200919069

Abstract

Abstract:

Totally 30 mice were randomly divided into young group, aging model group and salvianolic acid B (Sal B) treatment group. Aging model was successfully established by subcutaneous injection of D-galactose. Mice from Sal B treatment group were administered with a dose of 22.5 mg/kg through intraperitoneal injection. Morris water maze test and stand-jumping test were conducted at 6 weeks post-injection. The mice were scarified to determine superoxide dismutase (SOD) activity, malondialdehyde (MDA) and mitochondrial DNA (mtDNA) levels in brain tissue. Sal B treatment group exhibited better performance than aging model group on Morris water maze test and stand-jumping test. Moreover, Sal B treatment significantly reduced cerebral mtDNA and MDA levels and improved cerebral SOD activity in aging mice. Therefore, Sal B has the function to anti-aging due to the promotion of anti-oxidation and reduction of cerebral mtDNA level.

Key words: Sal B, anti-aging, SOD, MDA, mtDNA

CLC Number:

Q946.8

GAO Hui，HE Ling，LI Chun-yan，LU Jiang-ming. Effects and Mechanisms of Salvianolic Acid B on Learning Capability and Memory in Aging Mice[J]. FOOD SCIENCE, 2009, 30(19 ): 294-296 https://doi.org/10.7506/spkx1002-6630-200919069

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Effects and Mechanisms of Salvianolic Acid B on Learning Capability and Memory in Aging Mice

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