Abstract:

Objective: To study toxicological safety of peony seed oil. Methods: Acute toxicity test, sub-acute toxicity test and sperm abnormal genetic toxicity of peony seed oil were determined to evaluate its safety. Results: Acute toxicity test in mice demonstrated non-toxicity of peony seed oil due to its LD50 larger than 15 g/kg bw; sperm abnormal genetic toxicity test was negative, suggesting that no mutagenic effect arising from the administration of peony seed oil was observed; healthy rats were by gavage administered peony seed oil for 30 consecutive days and no abnormal changes in health status, biochemical indexes, hematological and blood biochemical indexes and immune organ indexes in the rats were observed after the end of the administration. Based on these results, it was estimated that the maximum non-effective dosage of peony seed oil was more than 5.0 g/kg bw (150 times as high as the recommended dosage for human body). Conclusion: Peony seed oil is excellent edible oil with higher safety.

Key words: peony seed oil, toxicology, acute toxicity, genetic toxicity