Abstract:

Objective: To study the effect of anthocyanin extracted from Lonicera caerulea residue (LCRA) on lipid metabolism and antioxidant function in high fat diet-induced obese rats. Methods: Rats were divided into 5 groups, inluding normal control group, obesity model group and LCRA low-, medium- and high-dose groups treated with LCRA at doses of 4.0, 40.0 mg/kg bw·d and 120 mg/kg bw·d. Normal control and obesity model groups were fed normal saline at the dose of 1.2 g/kg bw·d for 28 consecutive days. After administration, body and liver weight, body fat percentage, total triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), activities of HL, LPL, LPS, SOD and GSH-Px, and MDA content in liver were measured. Results: Compared with obesity model group, LCRA treated groups exhibited a significant reduction in serum lipid level and MDA content in liver and a significant increase in the activities of HL, LPL, LPS, SOD and GSH-Px in liver. Conclusion: LCRA can improve lipid metabolism in high fat diet-induced obese rats, which reveals strong functions for reducing peroxidative liver injury and preventing arteriosclerosis.

Key words: Lonicera caerulea residue, anthocyanin, lipid metabolism, antioxidant function