Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer,s Disease

doi:10.7506/spkx1002-6630-201107068

FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (7 ): 312-314.doi: 10.7506/spkx1002-6630-201107068

• Nutrition & Hygiene • Previous Articles Next Articles

Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer,s Disease

FANG Zheng-qing，LIU Chang-an，WANG Yuan-jin，ZHU Jie，BAI Mei

Research Institute of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine,
Hefei 230038, China

Received:2010-04-23 Revised:2011-02-14 Online:2011-04-15 Published:2011-03-30

Abstract

Abstract: Objective: To explore the effect of soybean isoflavone (SIF) on the expression of presenilin protein-1 (PS-1) in rats with Alzheimer's disease (AD). Methods: AD rat models were established by unilateral hippocampus injection of Aβ. The changes in learning and memory capability of AD rats were measured by step down test, the expression of PS-1 in hippocampus of rats were measured by immunohistochemical method. Results: Soybean isoflavone (SIF) could improve learning and memory capability of AD rats (P ＜ 0.01) by step down test, and significantly decrease the expression of PS-1 (P ＜ 0.01) in hippocampus of AD model group. Conclusion: Soybean isoflavone (SIF) can decrease PS-1 expression and improve learning and memory capability of AD rats.

Key words: soybean isoflavone, AD, β-amyloid peptide, presenilin protein-1

CLC Number:

R285.5

FANG Zheng-qing，LIU Chang-an，WANG Yuan-jin，ZHU Jie，BAI Mei. Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer,s Disease[J]. FOOD SCIENCE, 2011, 32(7 ): 312-314 https://doi.org/10.7506/spkx1002-6630-201107068

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Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer,s Disease

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