A Review of Angiotensin Converting Enzyme (ACE) Inhibitory Peptides Derived from Foods: Production and Quantitative Structure-Activity Relationship

Abstract

Abstract: Bioactive peptides are peptides with physiological functions in the body, such as immunomodulatory, antimicrobial, anticancer, antivirus, antithrombotic and antihypertension functions. Currently, peptides from foods with angiotensin converting enzyme (ACE) inhibitory activity are the focus of intense study. ACE plays a vital role in the regulation of blood pressure by producing potent vasoconstrictor angiotensine II, as well as by inactivating the vasodilating bradykinin. ACE inhibitory peptides have widely been produced by gastrointestinal digestion, fermentation and maturation process, enzymatic hydrolysis and genetic recombination. These inhibitory peptides may be incorporated into functional foods and several products are currently commercially available or under development. This paper presents an overview of antihypertensive peptides derived from food protein.

Key words: bioactive peptides, angiotensin converting enzyme (ACE), hypertension

CLC Number:

中图分类号：Q514+.3

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