Abstract:

The effect of seabuckthorn seed oil on the immobility time in mice was investigated by tail suspension test (TST) and
forced swimming test (FST). Body weight, sucrose preference and open-field activities were conducted on mice with depression
induced by chronic unpredictable mild stress (CUMS) to explore the antidepressant effect of seabuckthorn seed oil. The results
showed that administration of seabuckthorn seed oil was capable of reducing the immobility time in FST and TST while other
indices such as body weight, sucrose preference, open-field activities were increased significantly (P ＜ 0.05, 0.01). These findings
implicated that seabuckthorn seed oil might be a potential antidepressant for developing functional foods or drugs.

Key words: seabuckthorn seed oil, antidepression, tail suspension test (TST), forced swimming test (FST), chronic unpredicted mild stress (CUMS)