Progress in the Research of Synthetic Biology in Construction of Engineered Microorganisms

doi:10.7506/spkx1002-6630-20210831-414

Abstract

Abstract: As a new interdisciplinary subject that covers many fields in the 21st century, synthetic biology is of great help in exploring the basic laws of life activities and biotechnological innovations and breakthroughs. Synthetic biotechnology is a new approach to construct engineered microorganisms. It has been widely used to produce amino acids, organic acids, aromatic compounds, sugars, and so on. The yield of target products produced by recombinant engineered microorganisms can be efficiently increased by using advanced modules, systematic design and new genome editing methods to engineer the complex metabolic pathways in type strains, promoting the rapid development of social productivity. In this paper, the latest advances in the application of synthetic biology for the construction of engineered microorganism are reviewed, the developmental course of synthetic biotechnology is elaborated, and its application for the construction of engineered microorganism is exemplified. With the deepening of research on engineered microorganisms, synthetic biotechnology will bring new breakthroughs and opportunities for the fermentation industry.

Key words: synthetic biology; genome editing; metabolic regulation; construction of engineered microorganisms

CLC Number:

Q815

GAO Xin, LIU Yuzhe, JIANG Zeyuan, ZENG Qi, LIU Shimeng, LIU Xiaoting, MIN Weihong. Progress in the Research of Synthetic Biology in Construction of Engineered Microorganisms[J]. FOOD SCIENCE, 2022, 43(15): 256-264.

[1]	Shqan-Quan LIANG Shaoqing Yang Zheng-Qiang Jiang. Effect of the 2'-fucosyllactose Synthesis by different Pathway Configurations in Escherichia coli [J]. FOOD SCIENCE, 0, (): 0-0.
[2]	Xin GAO Min WeiHong. Research progress on construction of microbial engineering bacteria by synthetic biology [J]. FOOD SCIENCE, 0, (): 0-0.
[3]	Shi-Qi LIU Yu ZHAO Dong-Guang XIAO. Advances in the application of Kluyveromyces lactis as a microbial cell factory [J]. FOOD SCIENCE, 0, (): 0-0.
[4]	Feng-Ting ZHANG. Effect of Fusarium nivale and Aspergillus sojae on Transforming Hesperidin into Hesperitin-7-O-glucoside [J]. FOOD SCIENCE, 0, (): 0-0.
[5]	WANG Cang, MA Xiaoyi, TIAN Xiaopeng, ZU Hangtian, DING Yanshuai, LÜ Mingsheng, WANG Shujun. Screening and Identification of Marine Bacterium Pseudoalteromonas sp. HL9 and Characteristics of Phospholipase B Produced by It [J]. FOOD SCIENCE, 2022, 43(2): 134-141.
[6]	Cang WANG tian-xiaopeng xiaopengTIAN Mingsheng LYU. Screening and identification of marine Pseudoalteromonas sp. HL9 and the characteristics of phospholipase B [J]. FOOD SCIENCE, 0, (): 0-0.
[7]	Bo Guan Youzhen Hu. Screening and identification of lactic acid bacteria producing β-galactosidase with transgalactosylation activity from camel milk and enzymatic properties analysis [J]. , 0, (): 0-0.
[8]	Yu ZHAO Shi-Qi LIU. Advances in the application of Yarrowia lipolytica as a microbial cell factory [J]. , 0, (): 0-0.
[9]	ZHAO Yu, LIU Shiqi, LI Jian, LI Shenglong, ZHAO Yakun, XIAO Dongguang, YU Aiqun. Advances in the Application of Yarrowia lipolytica as a Microbial Cell Factory [J]. FOOD SCIENCE, 2021, 42(19): 388-400.
[10]	Bo Liu. Heterogeneity of ecological niche for fatty acid lipidomics in the ferment lysate during fermentation process of lactic acid bacteria [J]. FOOD SCIENCE, 0, (): 0-0.
[11]	Lei Chi Xiaolong Hu. Optimization of High Cell Density Cultivation of Recombinant Escherichia coli Producing Pullulanase based on Artificial Neural Network and Genetic Algorithm [J]. , 0, (): 0-0.
[12]	CHI Lei, WANG Jingyu, HOU Junchao, WEI Jiajia, WEI Tao, HU Xiaolong, HE Peixin. Artificial Neural Network-Genetic Algorithm-Based Optimization of High Cell Density Cultivation of Recombinant Escherichia coli for Producing Pullulanase [J]. FOOD SCIENCE, 2021, 42(10): 73-78.
[13]	蒙杨 Zheng-lian XUE. Effects of splicing of accessory protein gene on phospholipase A1 activity [J]. , 0, (): 0-0.
[14]	. Screening of the protease-producing strain and optimization of enzyme-producing conditions using rapeseed meal as a nitrogen source [J]. FOOD SCIENCE, 0, (): 0-0.
[15]	CHEN Sirui, TANG Linlin, FENG Jianwen, SUN Lina, WANG Jinling. Isolation and Identification of Yeast Capable of Efficiently Degrading Citric Acid and Its Acid Degradation Characteristics in Red Raspberry Juice [J]. FOOD SCIENCE, 2020, 41(22): 133-139.

Progress in the Research of Synthetic Biology in Construction of Engineered Microorganisms

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