FOOD SCIENCE ›› 2022, Vol. 43 ›› Issue (21): 191-202.doi: 10.7506/spkx1002-6630-20211010-089

• Nutrition & Hygiene • Previous Articles    

Saponins from Sea Cucumber Residues Protect against Cyclophosphamide-Induced Immunosuppression in Mice via the Nucleotide Binding and Oligomerization Domain-Like Receptor Signaling Pathway

ZHANG Ling, DONG Jingyuan, CHEN Yongde, LI Qian, WU Tao, LIU Rui, SUI Wenjie, ZHANG Min   

  1. (1. State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China; 2. Bestlife Biological Technology Co., Ltd., Tangshan 118300, China; 3. China-Russia Agricultural Processing Joint Laboratory, Tianjin Agricultural University, Tianjin 300392, China)
  • Published:2022-12-12

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Abstract: Sea cucumber is a traditional Chinese tonic with various bioactivities. This study systematically investigated the immunomodulatory effect of saponins extracted from sea cucumber residues (SCRSS) at doses of 2.5, 5.0 and 10.0 mg/(kg mb·d) on immunosuppressive mice. The results showed that SCRSS at a dose of 5.0 mg/(kg mb·d) increased the body mass, spleen index, and thymus index by 15.3%, 23.8%, and 39.8%, respectively, compared to the model control group, and it also significantly increased the phagocytic index in immunosuppressive mice (P < 0.01). Moreover, All the doses of SCRSS remarkably increased serum cytokine levels, promoted the proliferation activity of splenic lymphocytes and peritoneal macrophages. Importantly, the middle dose (5.0 mg/(kg mb·d)) of SCRSS was more effective to upregulate the expression of nucleotide binding and oligomerization domain (NOD)1, NOD2, receptor interacting protein 2 (RIP2) and nuclear factor (NF)-κB in immunosuppressive mice. Thus, SCRSS may be used as a functional food supplement to improve immunity.

Key words: sea cucumber residues; saponins; cyclophosphamide; immunomodulatory activity; nucleotide binding and oligomerization domain-like receptor

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