Research Progress on the Mechanisms by Which Natural Active Ingredients from Edible and Medicinal Fungi Regulate Uric Acid Metabolism

doi:10.7506/spkx1002-6630-20240902-010

FOOD SCIENCE ›› 2025, Vol. 46 ›› Issue (7): 328-336.doi: 10.7506/spkx1002-6630-20240902-010

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Research Progress on the Mechanisms by Which Natural Active Ingredients from Edible and Medicinal Fungi Regulate Uric Acid Metabolism

WEN Jing, YIN Chaomin, FAN Xiuzhi, SHI Defang, YAO Fen, YU Wei, GAO Hong

(1. School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China; 2. National Research and Development Center for Edible Fungi Processing, Institute of Agro-products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan 430064, China; 3. Key Laboratory of Cold Chain Logistics Technology for Agro-product, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China; 4. Hubei Xianggu Mushroom Industrial Technology Research Institute, Suizhou 441309, China)

Online:2025-04-15 Published:2025-03-19

Abstract

Abstract: Hyperuricemia (HUA) and gout are metabolic disorders caused by excessive levels of uric acid in the body. With the continuous improvement of living standards, the prevalence of HUA and gout has risen year after year, and patients with HUA or gout have become younger, posing a great threat to human health. Recent studies have found that certain natural active compounds in edible and medicinal fungi may have remarkable effects in alleviating HUA. This paper reviews the state-of-the-art research on the process of uric acid metabolism, the pathogenesis of HUA and gout, and the mechanisms through which major active components in edible and medicinal fungi regulate uric acid metabolism. The aim of this review is to provide a reference and guidance for the development and utilization of active compounds in edible and medicinal fungi.

Key words: hyperuricemia; gout; uric acid metabolism; edible and medicinal fungi; intestinal microbiota

CLC Number:

TS209

WEN Jing, YIN Chaomin, FAN Xiuzhi, SHI Defang, YAO Fen, YU Wei, GAO Hong. Research Progress on the Mechanisms by Which Natural Active Ingredients from Edible and Medicinal Fungi Regulate Uric Acid Metabolism[J]. FOOD SCIENCE, 2025, 46(7): 328-336.

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Research Progress on the Mechanisms by Which Natural Active Ingredients from Edible and Medicinal Fungi Regulate Uric Acid Metabolism

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