Nuciferine Alleviates Aging-Induced Renal Dysfunction by Inhibiting Angiotensin-Converting Enzyme

doi:10.7506/spkx1002-6630-20251216-131

Abstract

Abstract: This study investigated the protective effects and underlying mechanisms of nuciferine (NF) against aging-related renal dysfunction using mouse and cell models of D-galactose (D-gal)-induced aging and cellular models. The results demonstrated that 5 and 10 mg/kg NF treatment significantly ameliorated renal dysfunction, fibrosis, apoptosis, and inflammation in aging mice. Furthermore, 60 μmol/L NF markedly suppressed D-gal-induced senescence, fibrosis, and apoptosis in HK-2 cells. Meanwhile, NF effectively inhibited angiotensin-converting enzyme (ACE) activity and modulated the renin-angiotensin system, indicating that NF mitigates aging-associated renal injury through the regulation of ACE activity. In summary, NF serves as a potential natural dietary supplement for improving aging-associated renal dysfunction. This study provides a theoretical foundation for the development of NF-based functional health products.

Key words: nuciferine; aging; renal dysfunction; angiotensin-converting enzyme; renin-angiotensin system

CLC Number:

TS201.4

YANG Xiaojie, WANG Boyuan, ZHANG Juntao, PENG Ganfang, JI Jiatong, JIN Baoqi, WANG Weimin, HUANG Jianxin, YANG Haixia. Nuciferine Alleviates Aging-Induced Renal Dysfunction by Inhibiting Angiotensin-Converting Enzyme[J]. FOOD SCIENCE, 2026, 47(15): 154-164 https://doi.org/10.7506/spkx1002-6630-20251216-131

[1]	. Enzymatic Preparation of Large-Leaf Yellow Tea Oligosaccharides and Evaluation of Their Hypoglycemic, Hypolipidemic, and Gut Microbiota-Modulating Activities [J]. FOOD SCIENCE, 0, (): 0-0.
[2]	19952739617Y Weimin WANG. Nuciferine alleviates aging-induced renal dysfunction by inhibiting the angiotensin-converting enzyme [J]. FOOD SCIENCE, 0, (): 0-0.
[3]	. Effects of Ejiao Components on Gut Microbiota Composition and Structure in an In Vitro Simulated Intestinal Digestion–Fermentation System [J]. FOOD SCIENCE, 0, (): 0-0.
[4]	Zhen-Bao ZHU yang -Wei. Recent Advances in the Preparation, Purification, Identification, and Bioactivity of Tea Peptides [J]. FOOD SCIENCE, 0, (): 0-0.
[5]	ZHANG Andong, ZHANG Chuan, ZHANG Chengcheng, HUANG Pan, ZHAO Jianxin, ZHAI Qixiao, CHEN Wei, TIAN Fengwei. Effects of Asini Corii Colla (Ejiao) Components on Gut Microbiota Structure in an in Vitro Simulated Gastrointestinal Digestion and Fermentation System [J]. FOOD SCIENCE, 2026, 47(15): 114-123.
[6]	HE Xiong, LI Jiaxing, YOU Enzhuo, YUE Yuanyuan, Xu Huanhuan. Optimizing the Formulation of Low-Sodium Salt for Maintaining Healthy Blood Pressure Levels [J]. FOOD SCIENCE, 2026, 47(15): 133-140.
[7]	WANG Xinyi, WU Han, LI Yidi, LI Minni, XU Na, GE Huifang, WANG Yijun, XIE Zhongwen, LI Daxiang, WANG Hongyan. Enzymatic Preparation of an Oligosaccharide from Large-leaf Yellow Tea and Evaluation of Its Hypoglycemic, Hypolipidemic, and Gut Microbiota-Modulating Activities [J]. FOOD SCIENCE, 2026, 47(15): 165-178.
[8]	MA Wanning, ZHU Zhenbao, LIANG Lei, GU Haofeng, WEI Yang, WANG Jiahao, FU Yuyu, HU Jiaxue, NAN Xin, LIU Fei, YANG Jiayao, LUAN Yunbin. Recent Advances in the Preparation, Purification, Identification, and Bioactivity of Camellia sinensis L. Peptides [J]. FOOD SCIENCE, 2026, 47(15): 387-399.
[9]	ZHOU Simeng, ZHU Shangliang, CHU Weirong, ZHU Yuting, WANG Hongyan, WANG Yijun, XIE Zhongwen, LI Daxiang, GE Huifang. Combination of Lu’an Guapian Tea, Cassiae Semen and Lycium barbarum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease [J]. FOOD SCIENCE, 2026, 47(14): 17-30.
[10]	MENG Xiaolin, WEI Zhen, MA Ke, LI Xinyi, DU Yuxin, DENG Zhonglin, YA Lina, TANG Yayuan, WANG Zhenxing, HE Xuemei. Compositional Characteristics and in Vitro Bioactivities of Crude Polysaccharides from Jasmine Flowers at Different Blooming and Processing Stages [J]. FOOD SCIENCE, 2026, 47(14): 40-50.
[11]	DOU Yanhua, ZHANG Yugui, WAN Shunning, LIANG Zeng’enni. Essential Oil from Citrus aurantium L. var. amara Engl. Flowers Alleviates Depressive-like Behaviors in Mice via the Peripheral-Central-Energy Metabolism Pathway [J]. FOOD SCIENCE, 2026, 47(14): 203-213.
[12]	XU Jiaqi, LUO Tianting, REN Tingyuan. Effects and Mechanisms of Hydroxy-α-sanshool on the Redox State of Insulin-Resistant Cells [J]. FOOD SCIENCE, 2026, 47(14): 214-221.
[13]	ren Tingyuan. Effects and mechanisms of Hydroxy-Alpha-Sorbin on the intracellular redox state of insulin-antagonist cells [J]. FOOD SCIENCE, 0, (): 0-0.
[14]	yu xinDu Ya-Yuan TANG Zhen-Xing Wang Xue-Mei HE. Compositional Characteristics and In Vitro Bioactivities of Crude Polysaccharides from Jasmine Flowers at Different Raw Material States [J]. FOOD SCIENCE, 0, (): 0-0.
[15]	艳华窦. Peripheral-Central-Energy Metabolism Mediates the Improvement of Depressive-Like Behaviors in Mice by Citrus aurantium L. var. amara Engl. Flower Essential Oil [J]. FOOD SCIENCE, 0, (): 0-0.

Nuciferine Alleviates Aging-Induced Renal Dysfunction by Inhibiting Angiotensin-Converting Enzyme

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