Research Advances in the Mechanism for Gut Microbiota-Mediated Regulation of Intestinal Mucosal Immunity by Whole Grains

doi:10.7506/spkx1002-6630-20260515-125

Abstract

Abstract: In recent years, the mechanism underlying the cross-talk between the gut microbiota and host immunity has emerged as a research hotspot in nutritional immunology. Whole grains are rich in diverse bioactive components, including dietary fibers, polyphenols, phytosterols, and resistant starch. These components exert positive effects on the intestinal mucosal immune system by remodeling the gut microbiota, regulating immune cell differentiation, repairing the epithelial barrier, and inhibiting proinflammatory signaling pathways. This review summarizes the bioactive components of whole grains, alterations in the gut microbiota and their metabolites, and the modulation of intestinal mucosal immunity, aiming to provide a theoretical reference for immunonutrition research and clinical application of whole grains.

Key words: whole grains; gut microbiota; mucosal immunity; short-chain fatty acids; dietary fiber

CLC Number:

R151.3

XU Minhao, DING Yan, WANG Yitian, WANG Dongxu, YU Zhen, GUO Yuanxin. Research Advances in the Mechanism for Gut Microbiota-Mediated Regulation of Intestinal Mucosal Immunity by Whole Grains[J]. FOOD SCIENCE, 2026, 47(19): 344-357 https://doi.org/10.7506/spkx1002-6630-20260515-125

[1]	Zhi-Xian CHEN. Yeast Protein Reverses Cyclophosphamide-Induced Immunosuppression in Mice via the Gut-Immune Axis [J]. FOOD SCIENCE, 0, (): 0-0.
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[5]	. Lipid Composition and Comparative of Three Varities of Crassostrea gigas from Rushan [J]. FOOD SCIENCE, 0, (): 0-0.
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Research Advances in the Mechanism for Gut Microbiota-Mediated Regulation of Intestinal Mucosal Immunity by Whole Grains

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