Abstract:

Objective: To investigate the effect of intragastric administration of collagen II from sheep cartilage on the body weight and plantar thickness in mice with adjuvant arthritis. Methods: The optimal dosage of collagen II was screened using preliminary experiments. Mice were randomly divided into four groups, designated as control group (A), prevention group (B), treatment group (C) and model group (D). The body weight and plantar thickness in mice were measured at different time points before and after induction of inflammation. Results: The plantar thicknesses of groups B and C both began to markedly decrease from 12 and 14 days after inflammatory induction, respectively; the change trend of body weight initially decreased, followed by an increase. Group B was superior to group C in body weight recovery. However, body weight was inhibited but plantar thickness increased significantly after inflammatory induction in group D. Conclusion: Intragastric administration of collagen II can relieve inflammatory reaction in mice with adjuvant arthritis.

Key words: sheep cartilage, type II collagen, adjuvant arthritis, inhibition