HPLC Determination of Chlorpromazine Residue in Animal-derived Foods

doi:10.7506/spkx1002-6630-200914059

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (14): 269-271.doi: 10.7506/spkx1002-6630-200914059

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HPLC Determination of Chlorpromazine Residue in Animal-derived Foods

HONG Yue-ling1，HAO Xue-fei2，DONG Ke1

1. Zhengzhou Center for Disease Control and Prevention, Zhengzhou 450053, China；2. Research Center of Agricultural Quality
Standards and Testing Techniques, Henan Academy for Agricultural Sciences, Zhengzhou 450002, China

Received:2008-11-10 Revised:2009-01-15 Online:2009-07-15 Published:2010-12-29
Contact: HONG Yue-ling1 E-mail:dnavy@126.com

Abstract

Abstract:

A sensitive HPLC method was developed for the rapid determination of chlorpromazine residue in animal-derived foods. Samples were extracted with acetonitrile and cleaned up on a solid phase extraction column filled with alkaline alumina. Quantitative analyses were performed using the HPLC system equipped with a C18 column and a PDA detector. The mobile phase consisted of acetonitrile and 0.1% phosphoric acid (7:3, V/V) at a flow rate of 1.0 ml/min, and the detection wavelength was set at 254 nm. The limit of detection was 4 μg/kg and mean recoveries ranged from 80% to 101%. This method is accurate and feasible with simple pre-treatment for the detection of chlorpromazine residue in animal-derived foods.

Key words: animal-derived food, chlorpromazine residue, high performance liquid chromatography (HPLC)

CLC Number:

TS207.5

HONG Yue-ling1，HAO Xue-fei2，DONG Ke1. HPLC Determination of Chlorpromazine Residue in Animal-derived Foods[J]. FOOD SCIENCE, 2009, 30(14): 269-271 https://doi.org/10.7506/spkx1002-6630-200914059

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HPLC Determination of Chlorpromazine Residue in Animal-derived Foods

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