Preparation of Carboxymethyl- β-cyclodextrin

doi:10.7506/spkx1002-6630-200912017

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (12): 98-100.doi: 10.7506/spkx1002-6630-200912017

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Preparation of Carboxymethyl- β-cyclodextrin

WANG Jin，CHEN Jun-zhi

(College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China)

Received:2008-09-27 Revised:2009-01-08 Online:2009-06-15 Published:2010-12-29
Contact: WANG Jin， E-mail:wangjin_rose@126.com

Abstract

Abstract:

Carboxymethyl-β-cyclodextrin (CM-β-CD) was prepared in alkaline media by nucleophilic substitution reaction of β-CD and monochloroacetic acid. Influences of reaction temperature, reaction duration and reactant ratio on substitution degree and yield of CM-β-CD were discussed. Under optimized reaction conditions (reacting for 4 h at 60 ℃ and the molar ratios of monochloroacetic acid to β-CD and sodium hydroxide to monochloroacetic acid of 8.5:1 and 2.5:1, respectively), a substitution degree of 6.06 and a yield of 46% were achieved.

Key words: carboxymethyl- β-cyclodextrin, degree of substitution, preparation

CLC Number:

TS201.2

WANG Jin，CHEN Jun-zhi. Preparation of Carboxymethyl- β-cyclodextrin[J]. FOOD SCIENCE, 2009, 30(12): 98-100.

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Preparation of Carboxymethyl- β-cyclodextrin

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