Monoamine Oxidase-inhibiting and Anti-tumor Activities of Metabolites of Paecilomyces cicadae

doi:10.7506/spkx1002-6630-200911048

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (11): 216-218.doi: 10.7506/spkx1002-6630-200911048

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Monoamine Oxidase-inhibiting and Anti-tumor Activities of Metabolites of Paecilomyces cicadae

CHEN An-hui1，FAN Mei-zhen2,*，SHAO Ying1，CHEN Hong-wei1

(1. Department of Food (Biology) Engineering, Xuzhou Institute of Technology, Xuzhou 221008, China；
2. Anhui Provincial Key Laboratory of Microbial Pest Control, Hefei 230036, China)

Received:2008-10-06 Revised:2009-01-09 Online:2009-06-01 Published:2010-12-29
Contact: FAN Mei-zhen2,*， E-mail:mzfan@ahau.edu.cn

Abstract

Abstract:

With monoamine oxidase (MAO) as the target, the inhibitories activities of the methanol-ethyl acetate (1:1, V/V) extracts from the broth and mycelia of Paecilomyces cicadae RCEF0947 were investigated. It was found that the broth extract had good inhibitory activity against MAO-A, and the IC50 was 272.97 μg/ml; while for MAO-B, when the reaction concentration of sample was 400 mg/ml, both the extracts from broth and mycelia of RCEF0947 showed strong inhibitory activity with the IC50 of 538.37μg/ml and 509.36 μg/ml (no significant difference between them, p > 0.05), respectively. Meanwhile, a Resazurin cytotoxity assay model of Chinese hamster ovary cells (CHO) was employed to study the anti-tumor activity of extracts from the strain RCEF0947. The results revealed that both the extracts from broth and mycelia of RCEF0947 had strong anti-tumor activity with IC50 of 122.35μg/ml and 171.93μg/ml, respectively.

Key words: Paecilomyces cicadae, extract, monoamine oxidase (MAO), anti-tumor

CLC Number:

S646

CHEN An-hui1，FAN Mei-zhen2,*，SHAO Ying1，CHEN Hong-wei1. Monoamine Oxidase-inhibiting and Anti-tumor Activities of Metabolites of Paecilomyces cicadae[J]. FOOD SCIENCE, 2009, 30(11): 216-218.

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Monoamine Oxidase-inhibiting and Anti-tumor Activities of Metabolites of Paecilomyces cicadae

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