Safety Evaluation of Astragalus Polysaccharide

doi:10.7506/spkx1002-6630-200919074

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (19 ): 309-313.doi: 10.7506/spkx1002-6630-200919074

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Safety Evaluation of Astragalus Polysaccharide

ZHAORIGETU1，NA RISU1，HAN Jing-fen1，MA Chun-jie2，LING Xiao1，GERILETU BORIJIHAN1,*

1.Institute of Macromolecular Chemistry and Mongolian Medicine, Inner Mongolia University, Huhhot 010021, China；
2. Traditional Chinese Medical Department, Inner Mongolia Medical College, Huhhot 010110, China

Received:2009-07-21 Online:2009-10-01 Published:2010-12-29
Contact: GERILETU BORIJIHAN1,* E-mail:borjihan@imu.edu.cn

Abstract

Abstract:

Objective: To study toxicological safety of Astragalus polysaccharide as a health food or drug. Methods: Acute toxicity test in rats, mouse bone marrow cell micronucleus test, mouse sperm aberration test, Ames test and 30-day feeding study in rats were carried out. Results: Acute toxicity test indicated that the acute, oral maximum-tolerated dosage (MTD) of “Astragalus polysaccharide mastication tablets” to male and female rats were both more than 15.0 g/kg bw, which were equivalent to 300 times of the recommended value to human body. Therefore, this subject can be recognized as a non-toxic substance. All results of genotoxicity tests, including mouse bone marrow cell micronucleus test, mouse sperm aberration test and Ames test were negative. This revealed that no mutation occurred. In addition, 30-day feeding study in rats demonstrated all the doses of 5.00, 2.50 and 1.25 g/kg bw did not offer distinct adverse effects on the body weight, organ growth and blood biochemical indicators. Conclusion: Astragalus polysaccharide can be used as a health food or drug due to its better safety.

Key words: Astragalus polysaccharide, safety, toxicological test

CLC Number:

R114

ZHAORIGETU1，NA RISU1，HAN Jing-fen1，MA Chun-jie2，LING Xiao1，GERILETU BORIJIHAN1,*. Safety Evaluation of Astragalus Polysaccharide[J]. FOOD SCIENCE, 2009, 30(19 ): 309-313 https://doi.org/10.7506/spkx1002-6630-200919074

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Safety Evaluation of Astragalus Polysaccharide

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