Abstract: Objective:To research the hepatoprotective effects of Ganoderma lucidum peptides(GLP) against D-galactosamine(D-Gal)induced liver damage in mice.Method:Mice were randomly divided into five groups,namely normal,model and three GLP-treated groups.GLP-treated groups were daily given(ig) the doses at 60,120 and 180 mg GLP /kg bw respectively.Normal and model groups simultaneously received the same amount of physiological saline for 2 weeks.Then the mice from model group and GLP-treated groups were treated with 750 mg/kg bw D-Gal(ip).Aspartate transaminase/alanine transaminase(AST/ALT) activities in serum,malondialdehyde/glutathione(MDA/GSH) levels and superoxidedismutase(SOD) activity in liver were measured by the detection kits according to the manufacturer’s protocols.The liver histopathological characters were observed under light microscopy.Results:At the dose of 180mg/kg bw GLP,the ALT/AST activities in serum and MDA lever in liver were significantly reduced,SOD activity and GSH content in liver were significantly increased(p<0.05～0.01) when compared to model group.The liver histopathological characters were close to normal groups’.Conclusion:GLP possesses potent hepatoprotective effects against D-Gal-induced liver damage in mice.

Key words: Ganoderma lucidum peptides(GLP), liver damage, D-Galactosamine(D-Gal), hepatoprotective effect