FOOD SCIENCE ›› 2019, Vol. 40 ›› Issue (3): 173-177.doi: 10.7506/spkx1002-6630-20171030-359

• Nutrition & Hygiene • Previous Articles     Next Articles

Hepatoprotective Effect of Wild Blueberry Grown in China on Non-alcoholic Fatty Liver Disease

DING Huanhuan1, JING Zhixing2, XU Jianfeng1,*, LIU Haiquan2, ZHAO Yong2,3   

  1. (1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; 2. Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China; 3. Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China)
  • Online:2019-02-15 Published:2019-03-05

Abstract: Objective: To investigate the hepatoprotective effect of wild blueberry grown in China on non-alcoholic fatty liver disease. Methods: High-fat diet-induced obese mice were administrated with low, medium and high-dose blueberry homogenate (10, 20 and 40 g/(kg·d)) or blueberry anthocyanins (0.006, 0.012 and 0.024 g/(kg·d)) by gavage for 6 weeks. Then the activities of aspartate amino transferase (AST) and alanine amino transferase (ALT), and the contents of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in the sera of the mice as well as total antioxidant capacity (T-AOC) and the contents of glutathione (GSH) and malondialdehyde (MDA) in liver homogenates were determined. Results: Compared with the fatty liver model group, low-dose blueberry homogenate and medium- and high-dose blueberry anthocyanins significantly reduced the activities of AST and the ALT in mice (P < 0.05). Medium- and high-dose blueberry homogenate improved LDL-C content. Both the homogenate and anthocyanins at all doses significantly decreased TC and TG contents (P < 0.05) and at the medium and high doses could significantly increase T-AOC and GSH content and reduce MDA content in the liver of mice (P < 0.05). Conclusion: Anthocyanins from wild blueberry grown in China have good protective effects on non-alcoholic fatty liver disease.

Key words: wild blueberry grown in China, anthocyanin, non-alcoholic fatty liver, hepatoprotective effect

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