Study on Antitumor Effect and Immune Function of Carotenoids Extract from Potamogeton crispus L.

Abstract

Abstract: The antitumor activity and immune function of carotenoids from Potamogeton crispus L. (CEPC) were studied in thisarticle. Cyclophosphamide was the positive control and salad oil the negative control. H22-bearing mice were used as animalmodels. The changes of H22 tumor weight in vivo, the changes of MDA and SOD of liver in H22-bearing mice and the effect onimmune system such as DTH induced by DNFB, proliferation of lymphocytes and NK activity were investigated when differentdosage CEPC (5, 10, 20mg/kg·d) were used. It was shown that CEPC markedly inhibited tumor growth in the H22-bearing mice.It could also decrease MDA and increase SOD of liver in the H22-bearing mice. CEPC enhanced the immune function. So CEPChas both the antitumor effect and the immunity effect modulation.

Key words: Potamogeton crispus L., carotenoids, antitumor, H22, immune modulation

REN Dan-Dan, HUANG Hong-Xia, PENG Guang-Hua, WANG Hai-Bin, ZHANG Sheng-Hua. Study on Antitumor Effect and Immune Function of Carotenoids Extract from Potamogeton crispus L.[J]. FOOD SCIENCE, 2006, 27(3): 210-212.

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Study on Antitumor Effect and Immune Function of Carotenoids Extract from Potamogeton crispus L.

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