Recent Progress in Understanding the Bioactivity and Mechanism of Action of Lycium barbarum Polysaccharide

doi:10.7506/spkx1002-6630-20200212-118

FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (5): 349-359.doi: 10.7506/spkx1002-6630-20200212-118

• Reviews • Previous Articles

Recent Progress in Understanding the Bioactivity and Mechanism of Action of Lycium barbarum Polysaccharide

XIE Wen, CHEN Huaguo, ZHAO Chao, GONG Xiaojian, ZHOU Xin

（Guizhou Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Engineering Laboratory for Quality Control and Evaluation Technology of Medicine, Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China)

Online:2021-03-15 Published:2021-03-29

Abstract

Abstract: The fruit of Lycium barbarum is both a traditional Chinese medicinal material and dietary supplement, which contains various bioactive components, such as polysaccharides, flavonoids, alkaloids, pigments, and amino acids. A large number of studies showed that polysaccharides are the bioactive component with the highest extraction and utilization value in the fruit of Lycium barbarum due to its multiple biological functions such as anti-tumor, antioxidant, anti-aging, anti-inflammatory, hypoglycemic, hypolipidemic, neuroprotective, reproductive system-protecting, eye-protecting and immune-regulating effects. In this review, recent advances are systematically summarized in understanding the biological activities and mechanism of action of Lycium barbarum polysaccharide (LBP). Furthermore, future research directions and potential applications are presented. We hope that this review will provide useful information for the development of LBP-based nutraceuticals and auxiliary drugs.

Key words: Lycium barbarum polysaccharides; biological activities; mechanism of action; antitumor; antioxidant; neuroprotective effect; medicine and food homology

CLC Number:

TS255.1

XIE Wen, CHEN Huaguo, ZHAO Chao, GONG Xiaojian, ZHOU Xin. Recent Progress in Understanding the Bioactivity and Mechanism of Action of Lycium barbarum Polysaccharide[J]. FOOD SCIENCE, 2021, 42(5): 349-359.

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Recent Progress in Understanding the Bioactivity and Mechanism of Action of Lycium barbarum Polysaccharide

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