FOOD SCIENCE ›› 2006, Vol. 27 ›› Issue (5): 113-118.

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Iron-Binding Capacity of Lactoferrin in vitro and in vivo

 LU  Rong-Rong, SUN  Zhen, XU  Shi-Ying   

  1. 1.School of Food Science and Technology, Southern Yangtze University, Wuxi 214036, China; 2.Key Laboratory of Food Science and Safety; Ministry of Education, Wuxi 214036, China
  • Online:2006-05-15 Published:2011-09-16

Abstract:  The iron-binding capacity of lactoferrin was 87.7% produced by ultrafiltration and strong cation exchange chromatography. Its iron saturation point was 15.1%. Lactoferrin exhibited the strongest iron binding capacity at pH7.5 and 100 mmol/L of bicarbonate. In vivo study with SD rats showed that LF could significantly increase the concentration of hemoglobin at doses 50μg/g·d and 250μg/g·d. The low marginal dose level of LF was 50μg/g·d.

Key words:  , lactoferrin; iron-binding capacity;