Effects of Curcumin on Liver Injury of Mouse

Abstract

Abstract: Objective: To study on the reducing effect of curcumin on mouse liver injury caused by alcohol and fat. Methods: 30 mice were randomly divided into three groups, namely control, model and trial groups. The trail group was gastriclly administered with alcohol and curcumin plus high-fat feed. The mode group was administered only with alcohol plus high-fat diet to induce liver-damage. The control group was fed with ordinary daily diet. After four weeks, liver and serum were collected from tested animals. The MDA, GSH of homogenized liver tissues and the ALT, AST and LDH of serum were assessed. Results: In comparison with mode, a significant increase happened to GSH(p<0.05) but ALT and AST reducing (p<0.05) while MDA and LDH of trial group exhibited no significant difference. Conclusion: Curcumin can reduce liver injury.

Key words: curcumin, liver-damage

WANG Zheng, ZHANG Jing, HUI Bo-Di, GUO Yu. Effects of Curcumin on Liver Injury of Mouse[J]. FOOD SCIENCE, 2007, 28(10): 501-503.

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Effects of Curcumin on Liver Injury of Mouse

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