Abstract: Coenzyme Q10 (CoQ10), as dietary supplement or nutraceutical, is essential for cell respiration and electron transfer,helping control the production of energy in cells. The bioavailability of CoQ10 might be improved when using nanocapsule technology to prepare CoQ10 nanoliposomes. In this study,ethanol injection-sonication method was selected to prepare stable CoQ10 nanoliposomes with better microencapsulation quality. The encapsulation efficiency (EE), encapsulation yield (EY) and storage stability(including the change of transmittance at 500nm (T500nm) and the retention rate of core material (RR))of CoQ10 liposomes with eggyolk phosphatidylcholine (PC) as leading wall material were found better than those of CoQ10 liposomes with soybean PC when the loading capacity was higher. When using cholesterol and Tween 80 as adjuvant wall material, the product quality was improved evidently. The optimal wall formulation is obtained as follows: PC:Cholesterol: Tween 80=25:4:18 (W/ W). Under the conditions of optimal wall material formulation, both EE and RR of core material of CoQ10 nanoliposomes are higher than 95% when the ratio of CoQ10 to PC is increased to 20:25 (W/W, corresponding loading capacity is about 40%.).

Key words:  , coenzyme Q10； nanoliposomes； encapsulation efficiency； retention rate；