FOOD SCIENCE ›› 2008, Vol. 29 ›› Issue (10): 694-697.

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Research Developments of Anti-carcinogenic Mechanism of Proanthocyanidins

 YANG  Ying-Ying, WANG  Xue-Qing, PANG  Guang-Chang   

  1. Tianjin Key Laboratory of Food and Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China
  • Online:2008-10-15 Published:2011-12-08

Abstract: Proanthocyanidins are a class of phenolic oligomers or polymers that consisit of (+)-catechin and (-)-epicatechin. They have antioxidant,free radicals scavenging,antiinflammatory and anticancer activities. This paper summarized the latest research developments of anti-carcinogenic mechanism of proanthocyanidins about antioxidation,scavenging free radical,anti-inflammatory activity,regulatory signal transduction,pro-apoptotic effect,cell cycle arrest and inhibition of angiogenesis.

Key words: proanthocyanidins, antioxidant, anticancer, signal transduction, apoptosis