Study on Genetic Toxicity of Ursolic Acid to Bone Marrow Cells of Mice

Abstract

Abstract: Objective:To investigate the genetic toxicity of ursolic acid to bone marrow cell for its safety.Methods:By mouse bone marrow polychromatic erythrocyte micronucleus test,the micronucleus rate was measured.Mammalian bone marrow cell chromosome aberration test was persformed to assess the numbers of deformed chromosome.Results:The micronucleus rates and numbers of deformed chromosome of different groups of ursolic acid are all negative(compared with negative control p>0.05,compared with positive control p<0.05).Conclusion:Ursolic acid is nonmutagenic to somatic cell in mice.

Key words: ursolic acid, bone marrow cell micronucleus test, mammalian bone marrow cell chromosome aberration test

JIANG Wei, ZHANG Bo-Chao, SHAO Wei-Xuan, HE Xiao-Qing, ZHANG Cun-Hua, LU Jing. Study on Genetic Toxicity of Ursolic Acid to Bone Marrow Cells of Mice[J]. FOOD SCIENCE, 2008, 29(11): 585-587.

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Study on Genetic Toxicity of Ursolic Acid to Bone Marrow Cells of Mice

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