Abstract: 3,3-Dimethylbutylraldehy was synthesized with tertbutyl alcohol as main raw material by three-stage reaction,and then it and asparame were used to synthesize neotame. The effects of dosage of catalyst,molar ratio of aspartame to 3,3-dimethylbutylraldehyde,temperature and reaction time on the yield of neotame were studied. Through orthogonal test design,the optimum conditions are determined as:temperature 40 ℃,mass ratio of catalyst to aspartame 1:10,molar ratio of aspartame to 3,3-dimethylbutylraldehyde 1.5:1,and reaction time 10h. The total yield of neotame is 33.6%.

Key words: neotame, 3,3-dimethylbutyraldehyde, tertbutyl alcohol