Abstract:  In order to study the bioactivity of extract from pummelo peel, the antilipemic action and antitumor capacity of the extract were studied by mice in vivo. The sample group of mice had significantly lower concentration of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) (p<0.05), significantly higher concentration of high density lipoprotein cholesterol (HDL-C) (p<0.05) in serum of mice than that of the high lipid control group. The rate of inhibiting S180 growth in sample group was 29.7%. The mean wet weight of thymus gland of tumor control group was 1.2± 0.4mg/kg, significantly lower than that of the normal control group which was 2.6±0.8mg/kg (p<0.01), and the mean wet weight of thymus gland of sample group was 2.0±0.5mg/kg, significantly higher than that of the tumor control group (p<0.05). It shown that the extract could decease the lipemia concentration of white Kunming mice, inhibit the growth of tumor S180 and improve the immunity ability of the mice.

Key words:  , pummelo； extract； antilipemic； antitumor；