FOOD SCIENCE ›› 2013, Vol. 34 ›› Issue (11): 316-320.doi: 10.7506/spkx1002-6630-201311067

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Research Progress in Functions of Bioactive Chitooligosaccharides in Prevention and Treatment of Alzheimer’s Disease

ZHANG Jiao,DAI Xue-ling,JIANG Zhao-feng   

  1. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Research Institute for Science and Technology of Functional Food, Beijing Union University, Beijing 100191, China
  • Received:2012-03-04 Revised:2013-05-06 Online:2013-06-15 Published:2013-06-03


Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by the loss of
neuronal cells, intracellular neurofibrillar tangles and extracellular senile plaques. Chitooligosaccharide, also termed β-1,4-
oligomerization-glucosamine, is the alkaline oligosaccharide with multiple biological activities. Chitooligosaccharide
plays an important role in the prevention and treatment of AD by protecting neuronal cells from death, suppressing
hyperphosphorylation of tau, reducing the activity of β-secretase, antioxidation, chelating copper ions, and suppressing
the activity of acetylcholinesterase. In this paper, we have reviewed the recent research progress of chitooligosaccharide
on prevention and treatment of AD, which will provide a theoretical reference for the development and utilization of
chitooligosaccharide in health foods.

Key words: chitooligosaccharide;Alzheimer&rsquo, s disease;neuroprotective effects

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