Abstract: This study examined whether Lactobacillus rhamnosus B10 treatment can ameliorate ethanol-induced liver injury by antioxidant pathways in a mouse model of alcoholic steatohepatitis. Mice were randomly divided into control group, ethanol treatment group and L. rhamnosus B10 treatment group. After treatment for 8 weeks, blood samples were collected from the inferior vena cava of mice for the determination of serum ALT, LPS, MDA and SOD levels and mouse livers were observed for histopathological features and oxidative injury and analyzed for the contents of FFA (free fatty acids), TG and cholesterol. L. rhamnosus B10 treatment significantly relieved alcohol-induced fatty degeneration and oxidative injury in mice (P＜0.05), lowered the increase in the levels of serum ALT, LPS and MDA (P＜0.05), increased SOD activity (P＜0.05), and inhibited the increase in the levels of liver FFA, TG and cholesterol (P＜0.05). These findings suggest that L. rhamnosus B10 treatment can ameliorate alcohol-induced liver injury by antioxidant pathways in mice.

Key words: Lactobacillus rhamnosus B10, antioxidant, alcohol-induced liver injury