Abstract:

Objective: The protective effect of a refined polysaccharide fraction from Termitomyces albuminosus (RTAP) on
kidney, spleen and thymus in mice with acute alcoholic hepatic injury was investigated. Methods: The refined polysaccharide
from Termitomyces albuminosus was extracted by ultrasound-assisted hot water. Mice were randomly divided into blank
control group, alcoholic injury model group, positive control group (administered with 150 mg/(kg·d) bifendate by gavage)
and RTAP groups at doses of 100, 200 and 400 mg/(kg·d). All mice were administered for 30 days prior to administration
of 50% alcohol 12 mL/(kg·d) except that the blank control group was given an identical volume of saline. After alcohol
treatment, all mice were sacrificed through cervical dislocation and subjected to analysis of antioxidant capabilities in the
kidney, spleen and thymus. Results: Compared with the model control group, the contents of MDA in kidney, spleen and
thymus were obviously decreased, while the contents of GSH and activities of SOD, CAT and GSH-Px were obviously
increased in the RTAP treatment groups. Conclusion: RTAP has antioxidant effect on kidney and immune organs in mice
with alcoholic hepatic injury, and the mechanisms might be associated with its antioxidant activity.

Key words: Termitomyces albuminosus polysaccharide, antioxidant, alcohol injury, kidney, immune organs