Abstract:

Objective: To investigate the effect of endurance exercise combined with ginseng glycopeptide on blood
lipids and antioxidative capacity in hyperlipemia rats. Methods: A rat model of hyperlipidemia was induced by highfat
diet feeding for 8 weeks. The rats not fed with high-fat diet were selected as the normal control group (group N),
and the hyperlipidemia rats were randomly divided into four groups by total cholesterol, i.e., model control group
(group F), 80 mg/(kg·d) GGP group (group G), endurance exercise group (group E), 80 mg/(kg·d) GGP coupled with
endurance exercise group (group GE). Group E and group GE were subjected to small and medium-intensity running
training for 8 weeks. GGP preparation in normal saline was subcutaneously injected to the rats from group G and group
GE at a dose of 80 mg/(kg·d). The model rats were subjected to subcutaneous injection with normal saline for 8 weeks.
At the end of the experiment, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C),
low density lipoprotein cholesterol (LDL-C), apolipoproteins A1 (ApoA1) and B (ApoB), superoxide dismutase
(SOD), malondialdehyde (MDA), and glutathione (GSH) were determined. Results: Compared with group N, group F
showed significantly increased levels of TG, TC, LDL-C, ApoB and MDA (P ＜ 0.01 or P ＜ 0.001), but significantly
lowered levels of HDL-C, ApoA1 and SOD (P ＜ 0.01 or P ＜ 0.001). Compared with group F, the levels of TG, TC,
LDL-C, ApoB and MDA were increased significantly (P ＜ 0.05 or P ＜ 0.01 or P ＜ 0.001), while HDL-C, ApoA1
and SOD were significantly lower than in group E, group G and group GE (P ＜ 0.05 or P ＜ 0.001). Compared with
group E, TC level was significantly lower in group G (P ＜ 0.05), while SOD was increased significantly in group GE
(P ＜ 0.05). However, other indices decreased but no statistical difference was found (P ＞ 0.05). The levels of TC,
TG, LDL-C and ApoB were significantly lower in group GE (P ＜ 0.05 or P ＜ 0.01), and HDL-C, SOD and GSH were
increased significantly in group GE than in group E (P ＜ 0.05). Compared with group G, the levels of TG, LDL-C and
ApoB were significantly lower in group GE (P ＜ 0.05), while SOD and GSH were increased significantly in group GE
(P ＜ 0.05). Similarly, other indices exhibited a reduction, but no statistical difference was observed. Conclusion: Blood lipid
levels in hyperlipidemia rats are reduced in response to GGP injection combined with endurance exercise. This combination
exerts a better lipid-lowering effect than either alone.

Key words: ginseng glycopeptide, endurance exercise, hyperlipidemia, hypolipidemic, antioxidation