FOOD SCIENCE

Previous Articles     Next Articles

Effects of Blueberry Polyphenols on the Expression of iNOS and COX-2 Genes in Macrophages

HAN Cai-jing, CHENG An-wei, CHEN Xiang-yan, WANG Wen-liang, XIE Chun-yang   

  1. 1. Institute of Agro-food Science and Technology, Shandong Academy of Agricultural Sciences, Jinan 250100, China;
    2. College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China
  • Online:2014-10-15 Published:2014-10-17

RichHTML

4

PDF (PC)

161

Abstract:

The effects of different concentrations of extractable polyphenols (EPP) and non-extractable polyphenols
(NEPP) from blueberries on the mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in
lipopolysaccharides (LPS)-induced RAW264.7 cells at different culture times were studied in this paper. The results showed
that both EPP and NEPP from blueberries inhibited the mRNA expression of iNOS and COX-2 genes. During a 12-h
incubation period, the inhibitory effects of both EPP and NEPP, especially that of EPP, were significant. It is suggested that
EPP and NEPP have significant anti-inflammatory activity by inhibiting the mRNA expression of iNOS and COX-2 genes in
macrophages.

Key words: blueberry polyphenols, macrophages, iNOS, COX-2, gene expression

CLC Number: