A Review of Urolithins, Gut Microflora Metabolites of Dietary Ellagic Acid

doi:10.7506/spkx1002-6630-201507047

Abstract

Abstract:

Ellagitannins and ellagic acid are natural polyphenols widely distributed in pomegranate, strawberry, raspberry,
blackberry, grape and walnut. However, the absorption of ellagitannins and ellagic acid is extremely poor and the
unabsorbed ellagitannins and ellagic acid can be further metabolized to urolithins by the gut microbiota in the colon. It is
therefore conceivable that the health effects of ellagitannins-containing products can be associated with the gut-produced
urolithins, and thus, the evaluation of biological effects of these metabolites is essential. The present review covers the
recent studies concerning the chemical properties and biological activities of urolithins.

Key words: urolithins, ellagic acid, antioxidant, anti-inflammatory, anticancer

CLC Number:

TS201.4

YIN Peipei1, YAN Linlin1, CAO Ruoyu1, CHEN Xiaoyuan2, MA Chao1,*, LIU Yujun1,*. A Review of Urolithins, Gut Microflora Metabolites of Dietary Ellagic Acid[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201507047.

[1]	YIN Hongjie, JU Huapeng, ZHONG Limin, SUN Na, LIN Songyi. Biological Activity and Structural Characterization of Riboflavin-Binding Peptide [J]. FOOD SCIENCE, 2021, 42(9): 137-144.
[2]	BAI Haijun, LI Zhijiang. Effect of Taurine-Hydrolyzed Soybean Protein Composite System on Exercise-Induced Fatigue in Rats [J]. FOOD SCIENCE, 2021, 42(9): 145-150.
[3]	GUO Gangjun, HU Xiaojing, FU Jiarong, MA Shangxuan, XU Rong, HUANG Kechang, PENG Zhidong, HE Xiyong, ZOU Jianyun. Determination and Correlation Analysis of Functional Components and Antioxidant Activity of Successive Solvent Extracts from Macadamia Green Husk [J]. FOOD SCIENCE, 2021, 42(7): 74-82.
[4]	CHEN Shujun, ZHENG Jie. Dynamic Analysis of Organic Acids in a Mixture of Vegetable and Fruit Juices during Fermentation and Changes in Antioxidant Activity and Functional Constituents during Simulated Gastrointestinal Digestion [J]. FOOD SCIENCE, 2021, 42(7): 90-97.
[5]	XIAO Ying, XU Haojie, YANG Changming, SONG Xiaoqiu, ZHOU Xiaoli. Regulatory Effect of Cinnamon Essential Oil on Antioxidant Capacity of Liver and Intestine Tissues and Gut Microbiota in Mice [J]. FOOD SCIENCE, 2021, 42(7): 198-206.
[6]	SHI Pujie, XU Shiqi, WANG Zhenyu, WU Chao, LU Weihong, DU Ming. Advances in Biological Activity and Functional Mechanism of Peptides from Lactoferrin [J]. FOOD SCIENCE, 2021, 42(7): 267-274.
[7]	MAI Qiying, FAN Yawei, DENG Zeyuan, ZHANG Bing. Non-covalent Interaction Mechanism between Fetal Bovine Serum and Cyanidin-3-Glucoside and Its Effect on Antioxidant Activity of Cyanidin-3-Glucoside [J]. FOOD SCIENCE, 2021, 42(5): 1-8.
[8]	MEI Xing, WANG Guang, TIAN Rui, LIU Yu, XIA Lanxin, TIAN Cheng, LI Wei, CHENG Chao. Antioxidant Properties of Five Phycocyanins with Different Purities [J]. FOOD SCIENCE, 2021, 42(5): 17-23.
[9]	ZHANG Xuejiao, LIU Dengyong, Huimin David WANG. Antioxidant Activity in Vitro of Hydroxyproline Peptides [J]. FOOD SCIENCE, 2021, 42(5): 55-60.
[10]	LI Wei, YE Jiayi, CHEN Yunjiao, CAO Yong. Antioxidant Activity of Eucalyptus Leaf Polyphenol Extract in Vitro and in Vivo [J]. FOOD SCIENCE, 2021, 42(5): 160-168.
[11]	LI Mingliang, JIANG Sheng, GUO Ying, CHEN Liang, WANG Yuchen, CAI Muyi, GU Ruizeng, WEI Ying. Ameliorative Effect of Perilla Seed Peptide on Cyclophosphamide-Induced Sexual Function Impairment of Rats [J]. FOOD SCIENCE, 2021, 42(5): 177-186.
[12]	CHONG Fengting, HUANG Zizhen, TENG Jianwen, WEI Baoyao, HUANG Li, XIA Ning. Antioxidant Effect of Passion Fruit Peel and Its Effect on Inhibiting Glucose Absorption in Vitro and Regulating Intestinal Microflora Structure in Hyperglycemic Rats [J]. FOOD SCIENCE, 2021, 42(5): 193-200.
[13]	FAN Sanhong, WANG Jiaojiao, LI Jiani, BAI Baoqing. In Vivo Antioxidant Activity and Hypolipidemic Effect of Capsanthin and Capsaicin [J]. FOOD SCIENCE, 2021, 42(5): 201-207.
[14]	LI Yang, SU Yanyu, LI Guohao, LI Qi, WANG Yuxiang, DING Yusong. Antagonistic Effect of Quercetin against Oxidative Pancreatic Injury in Diabetic Rats via Nrf2 Pathway [J]. FOOD SCIENCE, 2021, 42(5): 208-214.
[15]	XIE Wen, CHEN Huaguo, ZHAO Chao, GONG Xiaojian, ZHOU Xin. Recent Progress in Understanding the Bioactivity and Mechanism of Action of Lycium barbarum Polysaccharide [J]. FOOD SCIENCE, 2021, 42(5): 349-359.

A Review of Urolithins, Gut Microflora Metabolites of Dietary Ellagic Acid

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments