Advances in Research on Neuron-Protective Role of Polyunsaturated Fatty Acids

doi:10.7506/spkx1002-6630-201607043

Abstract

Abstract:

The protective effects of polyunsaturated fatty acids (PUFAs) on brain function and the nervous system have
attracted a lot of attention. Numerous studies have illustrated the anti-inflammation, anti-oxidative and cardiovascular
protective effects of PUFAs, as well as the protective effects on brain function, particularly nerve cells. In this article,
we review the mechanisms of brain-protective effects of PUFAs in following fields: how PUFAs promote neurogenesis,
maintain nerve cell morphology and function, improve neurite growth; prevent neurodegeneration, depress nerve cell
apoptosis and regulate membrane fluidity, plasticity and telomere activity in neurons. This review provides a prospective
insight on nutritional studies of PUFAs against aging and/or diseases (such as Alzheimer’s disease and Parkinson’s disease)
inducing brain disorders.

Key words: polyunsaturated fatty acid, neurodegeneration, nerve cells, neurogenesis, brain function

CLC Number:

TS201.4

LIU Zhiguo, WANG Hualin, WANG Limei, LIU Lieju. Advances in Research on Neuron-Protective Role of Polyunsaturated Fatty Acids[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201607043.

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Advances in Research on Neuron-Protective Role of Polyunsaturated Fatty Acids

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