Study Progress of PPAR Gamma Regulation Mechanism of Adipocytes Proliferation and Differentiation

Abstract

Abstract: With the improvement of living standards, long-term intake of high calorie diet and lack of exercise, the excess energy is stored in body in the form of fat, and leads to obesity. Obesity has been officially listed as a chronic disease by WHO in 1997. Peroxisome proliferator-activated receptor (PPARs) regulate the adipocytes proliferation and differentiation binding with trans-acting element of the target gene. It has important theoretical significance and practical value of understanding the structural features, expression characteristics and mechanism of PPARs, to a series of diseases caused by obesity. This article reviewed from the aspect of the protein structure and gene expression of PPAR gamma, the ligands of activating of PPAR gamma, interaction between different type of PPARs, the function of PPAR gamma in lipid metabolism and natural ligands for the differentiation of adipocytes. The strategy of preventive of obesity was put forward from the angle of adipocytes proliferation regulation by PPAR gamma.

Key words: obesity, trans-acting elements, adipocyte, expression regulation

CLC Number:

Gu-Liang YANG. Study Progress of PPAR Gamma Regulation Mechanism of Adipocytes Proliferation and Differentiation[J]. FOOD SCIENCE, 0, (): 0-0.

References

[1] DUVAL C,CHINETTI G,TROTTEIN F,et al.The role of PPARs in atherosclerosis[J].Trends Mol Med,2002,8(9):422-430.
[2] GUAN Y.Targeting peroxisome proliferator-activated receptors (PPARs) in kidney and urologic disease[J].Minerva Urol Nefrol,2002, 54(2):65-79.
[3] CHINETTI G,FRUCHART JC,STAELS B.Peroxisome proliferator-activated receptors?(PPARs):nuclear receptors?at the crossroads between lipid metabolism and inflammation[J].Inflamm Res,2000,49(10):497-505.
[4] REDDY JK. Peroxisome proliferators and peroxisome proliferator-activated receptor α[J].The American Journal of Pathology,2004,164(6):2305-2321.
[5] KERSTEN S, DESVERGNE B, WAHLI W.Roles of PPARs in health and disease [J].Nature,2000,405(6785):421-424.
[6] MORAES LA，PIQUERAS L，BSSHOP-BAILEY D.Peroxisome proliferator-activated receptors and inflammation[J].Pharmacology & Therapeutics,2006,110(3):371-385.
[7] ISSEMANN I, GREEN S.Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators[J].Nature,1990,347(6294):1155-1208.
[8] ABBOTT BD.Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development [J].Reprod Toxicol,2009,27:246-257.DOI:10.1016/j.reprotox.2008.10.001.
[9] HSU M H, PALMER CN, SONG W, et al.A carboxyl terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding [J].J Biol Chem,1998,273(43):27988-27997.
[10] 樊月圆.肉牛PPARs家族和PLIN基因遗传变异及其与秦川牛胴体、肉质性状相关分析[D].杨凌:西北农林科技大学,2010:54-55.
[11] 王丽，那威，王宇祥，等.鸡PPARγ基因的表达特性及其对脂肪细胞增殖分化的影响[J].遗传,2012(4):454-464.DOI:10.3724/SP.J.1005.2012.00454.
[12] GUO L,?SUN B,?SHANG Z, et al.Comparison of adipose tissue cellularity in chicken lines divergently selected for fatness[J].Poult Sci,2011,90(9):2024-2034.DOI: 10.3382/ps.2010-00863.
[13] PETROVIC N,?WALDEN TB,?SHALINA IG et al.Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived whiteadipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes[J].J Biol Chem,2010,285(10):7153-7164.DOI: 10.1074/jbc.M109.053942.
[14] CHOIi SH,?CHUNG KY,?JOHNSON BJ, et al.Co-culture of bovine muscle satellite cells with preadipocytes increases PPARγ and C/EBPβ gene expression in differentiated myoblasts and increases GPR43 gene expression in adipocytes[J].J Nutr Biochem,2013, 24(3):539-543.DOI: 10.1016/j.jnutbio.2012.01.015.
[15] MANDARD S, MULLER M, KERSTEN S.Peroxisome proliferator-activated receptor alpha target genes[J].Cell Mol Life Sci,2004,61, 393-416.?DOI: 10.1155/2010/612089.
[16] AHMED W, ZIOZENKOVA O, BROWN J, et al.PPARs and their metabolic modulation: new mechanisms for transcriptional regulation[J].J Intern Med,2007, 262, 184-198.
[17] COSTET P, LEGENDRE C, MORé J, et al.Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis[J].J Biol Chem,1998, 273(45):29577-29585.
[18] DELUCA JG, DOEBBER TW, KELLY LJ, et al.Evidence for peroxisome proliferator-activated receptor (PPAR)alpha-independent peroxisome proliferation: effects of PPARgamma/delta-specific agonists in PPARalpha-null mice[J].Mol Pharmacol,2000, 58(3):470-476.
[19] BRUN RP, TONTONOZ P, FORMAN BM, et al.Differential activation of adipogenesis by multiple PPAR isoforms[J].Genes Dev,1996, 10(8):974-984.
[20] WU Z, ROSEN ED, BRUN R,et al.Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity[J].Mol Cell,1999, 3(2):151-158.
[21] SPIEGELMAN BM, FLIER JS.Adipogenesis and obesity: rounding out the big picture[J].Cell,1996,87(3):377-389.
[22] MANDRUP，MDL.Regulating adipogenesis[J].J Biol Chem,1997,272(9):5367-5370.
[23] CHAWLA A, LAZAR MA.Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival[J].Proc Natl Acad Sci U S A, 1994,91(5): 1786-1790.
[24] AILHAUD G.Molecular mechanisms of adipocyte differentiation.J Endocrino,1997,155(2):201-202.
[25] SIERSBAEK R,?NIELSEN R,?MANDRUP S.PPARgamma in adipocyte differentiation and metabolism-novel insights from genome-wide studies[J].FEBS Lett,2010,584(15):3242-3249. DOI: 10.1016/j.febslet.2010.06.010.
[26] ROSEN ED,?HSU CH,?WANG X,?et al. C/EBPalpha?induces?adipogenesis?through PPARgamma: a unified pathway[J]. Genes Dev, 2002, 16(1):22-26.
[27] MATSUSUE K，PETERS JM，GONZALEZ FJ.PPARβ/δ potentiates PPARγ-stimulated adipocyte differentiation[J].Faseb Journal,2004,18(12):1477-1479
[28] CHOI JH,?BANKS AS,?ESTALL JL, et al.Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5[J].Nature,2010, 466(7305):451-456.DOI: 10.1038/nature09291.
[29] LI P,?FAN W,?XU J, et al.Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity[J].Cell,2011, 147(4): 815-26.DOI: 10.1016/j.cell.2011.09.050.
[30] KAWAI M,?ROSEN CJ.PPARγ: a?circadian?transcription factor in adipogenesis and osteogenesis[J].Nat Rev Endocrinol,2010,6(11): 629-636.DOI: 10.1038/nrendo.2010.155.
[31] AHMED M,?GAFFEN SL.IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors[J].Cytokine,2013, 61(3): 898-905.DOI: 10.1016/j.cyto.2012.12.007.
[32] KIM SY,?KIM AY,?LEE HW, et al.miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression[J].Biochem Biophys Res Commu,2010,392(3): 323-328.DOI: 10.1016/j.bbrc.2010.01.012.
[33] 吴宗松.miR-27b通过靶向于PPARγ触发脂肪细胞分化[D].杨凌:西北农林科技大学,?2009:40-41.
[34] MEERSON A,?TRAURIG M,?OSSOWSKI V, et al.Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α[J].Diabetologia,2013,56(9):1971-1979.DOI: 10.1007/s00125-013-2950-9.
[35] PARK HS,?JU U,?PARK JW, et al.PPARγ neddylation essential for adipogenesis is a potential target for treating obesity[J].Cell Death Differ,2016.3.18.DOI: 10.1038/cdd.2016.6. ?[Epub ahead of print]
[36] BURNS KA, VANDEN HJP.Modulation of PPAR activity via phosphorylation [J].Biochim Biophys Acta,2007,1771(8):952-960.
[37] YU YH,?CHANG YC,?SU TH, et al.Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity[J].J Lipid Res.?2013,54(9):2391-2399.DOI:10.1194/jlr.M037556.
[38] ZHENG W,?FENG X,?QIU L, et al.Identification?of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes[J].Diabetologia,2013,56(2):401-411.DOI: 20.1007/s00125-012-2777-9.
[39] FENG L,?LUO H,?XU Z, et al.Bavachinin, as a novel natural pan-PPAR?agonist, exhibits unique synergistic effects with synthetic?PPAR-γ andPPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice[J].Diabetologia,2016.3.16. [Epub ahead of print].
[40] 毛磊,徐慧,田迎樱等.叶瓜参长链碱抑制3T3-L1前脂肪细胞分化及其作用机制研究[J].食品科学,2015.10.9,网络预发表.
[41] 王振华,邱理红,王占洋等.异甘草素对3T3-L1前脂肪细胞分化的抑制作用[J].食品科学, 2015.6.17,网络预发表.
[42] 金凤，康凯夫，陈坚平．p53、MDM2、eyelin G在星形细胞瘤中的表达及与肿瘤分化和预后的关系[J]．实用医学杂志，2007, 23(11): 1635-1637.
[43] GARCIA-ROJAS P,?ANTARAMIAN A,?GONZáLEZ-DáVALOS L,?et al.Induction of peroxisomal proliferator-activated receptor gamma and peroxisomal proliferator-activated receptor gamma coactivator 1 by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue[J].J Anim Sci,2010,88(5):1801-1808.DOI: 10.2527/jas.2009-2579.
[44] TAXVIG C,?DREISIG K,?BOBERG J, et al.Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation[J].Mol Cell Endocrinol,2012,361(1-2):106-115.DOI:10.1016/j.mce.2012.03.021.
[45] DIEZKO R,?SUSKE G.Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain[J].PLoS One,2013,24;8(6):e66947.DOI: 10.1371/journal.pone.0066947.
[46] TSUKAMOTO T, NAKATA R, TAMURA U, et al.Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo[J].Nutrition & Metabolism,2010,?7(1):1-8
[47] SONG M,?TIAN X,?LU M,?et al.Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via?PPARγ pathway[J].Int J Oncol,2015,46(3)1131-1140.DOI:10.3892/ijo.2015.2829.
[48] GOTO T,?KIM YI,?FUNAKOSHI K, et al. Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both?PPARα-dependent and -independent pathways[J]. Am J Physiol Endocrinol Metab.?2011, 301(5):E1022-1032. DOI: 10.1152/ajpendo.00061.2011.
[49] SOUBH AA,?AADALLAH DM,?El-ABBAR HS.Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and?PPARγ signaling pathways[J].Life Sci,2015, 136:142-150.DOI: 10.1016/j.lfs.2015.07.004.
[50] SHANG W,?YANG Y,?JIANG B,?et al.Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression[J].Life Sci,2007,23,80(7): 618-625.
[51] HAN KL,?JUNG MH,?SOHN JH,?et al.Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes[J].Biol Pharm Bull,2006, 29(1):110-113.
[52] YANG Y,?SHANG W,?ZHOU L, et al.Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells[J].Biochem Biophys Res Commun,2007, 353(2):225-230.
[53] ZHOU Y,?ZHENG S,?LIN J,?et al.The interruption of the PDGF and EGF signaling pathways by?curcumin?stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro[J].Lab Invest,2007,87(5):488-498.
[54] GONG Z, HUANG C, SHENG X, et al.The role of Tanshinone IIA in the Treatment of Obesity through PPAR{gamma} Antagonism[J].Endocrinology,2008,150(1):104-113. DOI:?10.1210/en.2008-0322.
[55] HUANG C,?ZHANG Y,?GONG Z, et al.Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway[J].Biochem Biophys Res Commun,2006,348(2):571-578.
[56] 刘毅，王文健，陈伟华，等.黄芪多糖对3T3-L1前脂肪细胞增殖和分化的影响[J].中西医结合杂志,2007,5(4):421-426.
[57] 窦勤，魏媛媛，李郁，等.石榴花多酚对糖尿病大鼠IL-6、TXB2及PPAR-γ mRNA基因表达的影响[J].中国药理学通报,2010,26(6):794-797.
[58] 傅晓东，何燕铭，陈伟华，等.蒲黄总黄酮对3T3-L1前脂肪细胞增殖分化及相关基因表达的影响[J].医学研究生学报,2010,23(5):456-459.