Progress in Research on Biological Activity and Functions of Ribosome-Inactivating Proteins in Bitter Mellon

doi:10.7506/spkx1002-6630-201613041

Abstract

Abstract:

Ribosome-inactivating proteins (RIPs) are a family of protein than can remove A4324 from the highly conserved
and surface-exposed sarcin/ricin loop (SRL) in the 28S rRNA of eukaryotic ribosomes. The depurination destroys the
interaction between elongation factors and ribosome, thereby resulting in the inactivation of ribosome and the inhibition of
protein synthesis. RIPs can be classified into type I, type II and type III. The RIPs identified in Momordica charantia L.,
such as α-momorcharin, β-momorcharin, γ-momorcharin, δ-momorcharin, ε-momorcharin and MAP30, all belong to the type
I RIPs. Antiviral, antibacterial, pesticidal and anti-tumor, hypolipidemia, hypoglycemia and other biologically activities have
been reported for these RIPs. In this article, the classification, biologically activity, function and application of RIPs have
been reviewed in the hope of providing a theoretical basis for further development and utilization of bitter mellon RIPs.

Key words: Momordica charantia L., ribosome-inactivating proteins (RIPs), classification, biological activity, function

CLC Number:

S482.8

YANG Guliang, LI Shiming, WANG Shuzhen. Progress in Research on Biological Activity and Functions of Ribosome-Inactivating Proteins in Bitter Mellon[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201613041.

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