Combined Mutation of Monascus and Optimization of Fermentation Conditions for Monacolin K Production

doi:10.7506/spkx1002-6630-201211052

Abstract

Abstract: A strain of Monascus purpureu was treated with UV irradiation and its spore was then incubated in media containing LiCl to induce mutation. A mutant strain with high yield of monacolin K was obtained and its fermentation conditions were optimized for monacolin K production. The results showed that the optimal fermentation conditions were initial temperature of 30 ℃, late temperature of 24 ℃ and original moisture content of germinated brown rice of 60%. Under these conditions, the yield of monacolin K reached 5.33 mg/g.

Key words: Monascus, combined mutation, monacolin K, response surface methodology

CLC Number:

Q939.99

YANGHuan-huan，HUZhong-ze. Combined Mutation of Monascus and Optimization of Fermentation Conditions for Monacolin K Production[J]. FOOD SCIENCE, 2012, 33(11): 247-251.

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Combined Mutation of Monascus and Optimization of Fermentation Conditions for Monacolin K Production

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