Amelioration of retinal photo-oxidative stress by dietary nutrient components and the mechanism: A review

Abstract

Abstract: With the popularity of electronic devices (e.g. mobile phones, tablets, computers, etc.) and various lighting products, the incidence of visual light-induced retinal damage has increased dramatically, becoming a major cause of visual health hazards in modern society. A growing number of studies have found that dietary supplementation with nutrients such as anthocyanins, carotenoids, long-chain unsaturated fatty acids and vitamin A is effective in improving vision and enhancing the retina's resistance to oxidative stress. Therefore, this work reviews the mechanisms of retinal photodamage and, on this basis, discusses the role of different dietary nutrients in improving visible light-induced retinal injury and the corresponding regulatory mechanisms. This review can provide scientific basis for preventing and ameliorating retinal photodamage through dietary supplementation.

Key words: retinal, oxidative stress, anthocyanins, carotenoids, dietary nutrition

CLC Number:

TS201.6

Xiang YiLIU. Amelioration of retinal photo-oxidative stress by dietary nutrient components and the mechanism: A review[J]. FOOD SCIENCE, 0, (): 0-0.

References

参考文献
[1] Narayan D S, Wood J P, Chidlow G, et al. A review of the mechanisms of cone degeneration in retinitis pigmentosa[J]. Acta Ophthalmol, 2016,94(8):748-754.DOI:10.1111/aos.13141.
[2] Alaimo A, Linares G G, Bujjamer J M, et al. Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration[J]. Arch Toxicol, 2019,93(5):1401-1415.DOI:10.1007/s00204-019-02409-6.
[3] Tangvarasittichai O, Tangvarasittichai S. Oxidative Stress, Ocular Disease and Diabetes Retinopathy[J]. Curr Pharm Des, 2018,24(40):4726-4741.DOI:10.2174/1381612825666190115121531.
[4] Bruce A. Re: Holden et al.: Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050 (Ophthalmology 2016;123:1036-1042)[J]. Ophthalmology, 2017,124(3):e24-e25.DOI:10.1016/j.ophtha.2016.06.066.
[5] Grzybowski A, Kanclerz P, Tsubota K, et al. A review on the epidemiology of myopia in school children worldwide[J]. BMC Ophthalmol, 2020,20(1):27.DOI:10.1186/s12886-019-1220-0.
[6] Jonas J B, Cheung C, Panda-Jonas S. Updates on the Epidemiology of Age-Related Macular Degeneration[J]. Asia Pac J Ophthalmol (Phila), 2017,6(6):493-497.DOI:10.22608/APO.2017251.
[7] Wong W L, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis[J]. Lancet Glob Health, 2014,2(2):e106-e116.DOI:10.1016/S2214-109X(13)70145-1.
[8] 王勇. 多酚对视网膜光氧化损伤的预防功效及作用机制初步研究[D]. 中国农业大学, 2017.
[9] Kalt W, Cassidy A, Howard L R, et al. Recent Research on the Health Benefits of Blueberries and Their Anthocyanins[J]. Adv Nutr, 2020,11(2):224-236.DOI:10.1093/advances/nmz065.
[10] Silvan J M, Reguero M, de Pascual-Teresa S. A protective effect of anthocyanins and xanthophylls on UVB-induced damage in retinal pigment epithelial cells[J]. Food Funct, 2016,7(2):1067-1076.DOI:10.1039/c5fo01368b.
[11] Mares J. Lutein and Zeaxanthin Isomers in Eye Health and Disease[J]. Annu Rev Nutr, 2016,36:571-602.DOI:10.1146/annurev-nutr-071715-051110.
[12] Yang S, Zhou J, Li D. Functions and Diseases of the Retinal Pigment Epithelium[J]. Front Pharmacol, 2021,12:727870.DOI:10.3389/fphar.2021.727870.
[13] Rozanowska M B. Light-induced damage to the retina: current understanding of the mechanisms and unresolved questions: a symposium-in-print[J]. Photochem Photobiol, 2012,88(6):1303-1308.DOI:10.1111/j.1751-1097.2012.01240.x.
[14] Park P S. Supramolecular organization of rhodopsin in rod photoreceptor cell membranes[J]. Pflugers Arch, 2021,473(9):1361-1376.DOI:10.1007/s00424-021-02522-5.
[15] Daruwalla A, Choi E H, Palczewski K, et al. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle[J]. Biochem J, 2018,475(20):3171-3188.DOI:10.1042/BCJ20180193.
[16] Kaylor J J, Xu T, Ingram N T, et al. Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate[J]. Nat Commun, 2017,8(1):16.DOI:10.1038/s41467-017-00018-4.
[17] Saari J C. Vitamin A metabolism in rod and cone visual cycles[J]. Annu Rev Nutr, 2012,32:125-145.DOI:10.1146/annurev-nutr-071811-150748.
[18] Noell W K, Albrecht R. Irreversible effects on visible light on the retina: role of vitamin A[J]. Science, 1971,172(3978):76-79.DOI:10.1126/science.172.3978.76.
[19] Grimm C, Wenzel A, Hafezi F, et al. Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration[J]. Nat Genet, 2000,25(1):63-66.DOI:10.1038/75614.
[20] Olchawa M, Krzysztynska-Kuleta O, Duda M, et al. In vitro phototoxicity of rhodopsin photobleaching products in the retinal pigment epithelium (RPE)[J]. Free Radic Res, 2019,53(4):456-471.DOI:10.1080/10715762.2019.1603377.
[21] Contin M A, Arietti M M, Benedetto M M, et al. Photoreceptor damage induced by low-intensity light: model of retinal degeneration in mammals[J]. Mol Vis, 2013,19:1614-1625.
[22] Xie T, Zhang Z, Fang Q, et al. Structural basis of substrate recognition and translocation by human ABCA4[J]. Nat Commun, 2021,12(1):3853.DOI:10.1038/s41467-021-24194-6.
[23] Maeda T, Golczak M, Maeda A. Retinal photodamage mediated by all-trans-retinal[J]. Photochem Photobiol, 2012,88(6):1309-1319.DOI:10.1111/j.1751-1097.2012.01143.x.
[24] Li J, Zhang Y, Cai X, et al. All-trans-retinal dimer formation alleviates the cytotoxicity of all-trans-retinal in human retinal pigment epithelial cells[J]. Toxicology, 2016,371:41-48.DOI:10.1016/j.tox.2016.10.005.
[25] Ablonczy Z, Gutierrez D B, Grey A C, et al. Molecule-specific imaging and quantitation of A2E in the RPE[J]. Adv Exp Med Biol, 2012,723:75-81.DOI:10.1007/978-1-4614-0631-0_11.
[26] 曾纯, 蔡善君. RPE细胞光损伤机制的研究进展[J]. 医学综述, 2018,24(08):1509-1514.
[27] Luo M M, Chen L, Wang S, et al. The Effect of A2E on the Uptake and Release of Calcium in the Lysosomes and Mitochondria of Human RPE Cells Exposed to Blue Light[J]. J Ophthalmol, 2021,2021:5586659.DOI:10.1155/2021/5586659.
[28] Wu Y, Yanase E, Feng X, et al. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration[J]. Proc Natl Acad Sci U S A, 2010,107(16):7275-7280.DOI:10.1073/pnas.0913112107.
[29] Donato L, D'Angelo R, Alibrandi S, et al. Effects of A2E-Induced Oxidative Stress on Retinal Epithelial Cells: New Insights on Differential Gene Response and Retinal Dystrophies[J]. Antioxidants (Basel), 2020,9(4).DOI:10.3390/antiox9040307.
[30] Arunkumar R, Gorusupudi A, Li B, et al. Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4(-/-)/Bco2(-/-) double knockout mice[J]. Exp Eye Res, 2021,209:108680.DOI:10.1016/j.exer.2021.108680.
[31] Cheng Y S, Linetsky M, Gu X, et al. Light-induced generation and toxicity of docosahexaenoate-derived oxidation products in retinal pigmented epithelial cells[J]. Exp Eye Res, 2019,181:325-345.DOI:10.1016/j.exer.2018.09.012.
[32] 彭珍珍, 綦文涛, 王勇, 等. 花色苷对视网膜的保护作用及其机制研究进展[J]. 食品科学, 2022,43(09):249-257.
[33] Liu Y, Zhang D, Hu J, et al. Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols[J]. J Agric Food Chem, 2015,63(42):9295-9305.DOI:10.1021/acs.jafc.5b04341.
[34] Giannaccare G, Pellegrini M, Senni C, et al. Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights[J]. Mar Drugs, 2020,18(5).DOI:10.3390/md18050239.
[35] Wang Y, Zhao L, Wang C, et al. Protective effect of quercetin and chlorogenic acid, two polyphenols widely present in edible plant varieties, on visible light-induced retinal degeneration in vivo[J]. Journal of Functional Foods, 2017,33:103-111.DOI:https://doi.org/10.1016/j.jff.2017.02.034.
[36] Kuse Y, Tsuruma K, Kanno Y, et al. CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure[J]. Front Pharmacol, 2017,8:207.DOI:10.3389/fphar.2017.00207.
[37] Gorbatyuk M S, Starr C R, Gorbatyuk O S. Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases[J]. Prog Retin Eye Res, 2020,79:100860.DOI:10.1016/j.preteyeres.2020.100860.
[38] Kroeger H, Chiang W C, Felden J, et al. ER stress and unfolded protein response in ocular health and disease[J]. FEBS J, 2019,286(2):399-412.DOI:10.1111/febs.14522.
[39] Gorbatyuk M S, Starr C R, Gorbatyuk O S. Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases[J]. Prog Retin Eye Res, 2020,79:100860.DOI:10.1016/j.preteyeres.2020.100860.
[40] Park Y S, Kim H L, Lee S H, et al. Expression of the Endoplasmic Reticulum Stress Marker GRP78 in the Normal Retina and Retinal Degeneration Induced by Blue LED Stimuli in Mice[J]. Cells, 2021,10(5).DOI:10.3390/cells10050995.
[41] 刘霞, 王艳, 江华维, 等. 内质网应激在年龄相关性黄斑变性中的研究进展[J]. 国际眼科杂志, 2022,22(02):244-248.
[42] McLaughlin T, Medina A, Perkins J, et al. Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications[J]. Mol Neurodegener, 2022,17(1):25.DOI:10.1186/s13024-022-00528-w.
[43] González C M, García A L, Llorca E, et al. Carotenoids in dehydrated persimmon: Antioxidant activity, structure, and photoluminescence[J]. LWT, 2021,142:111007.DOI:https://doi.org/10.1016/j.lwt.2021.111007.
[44] Rodriguez-Concepcion M, Avalos J, Bonet M L, et al. A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health[J]. Prog Lipid Res, 2018,70:62-93.DOI:10.1016/j.plipres.2018.04.004.
[45] Avila-Roman J, Garcia-Gil S, Rodriguez-Luna A, et al. Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids[J]. Mar Drugs, 2021,19(10).DOI:10.3390/md19100531.
[46] Li L H, Lee J C, Leung H H, et al. Lutein Supplementation for Eye Diseases[J]. Nutrients, 2020,12(6).DOI:10.3390/nu12061721.
[47] Bian Q, Gao S, Zhou J, et al. Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells[J]. Free Radic Biol Med, 2012,53(6):1298-1307.DOI:10.1016/j.freeradbiomed.2012.06.024.
[48] Martin A N, Leung M, Radhakrishnan R, et al. Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye[J]. Nutrients, 2021,13(11).DOI:10.3390/nu13113987.
[49] Bungau S, Abdel-Daim M M, Tit D M, et al. Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases[J]. Oxid Med Cell Longev, 2019,2019:9783429.DOI:10.1155/2019/9783429.
[50] Catanzaro E, Bishayee A, Fimognari C. On a Beam of Light: Photoprotective Activities of the Marine Carotenoids Astaxanthin and Fucoxanthin in Suppression of Inflammation and Cancer[J]. Mar Drugs, 2020,18(11).DOI:10.3390/md18110544.
[51] 张冠华, 刁倩楠. 类胡萝卜素研究进展[J]. 现代农业, 2021(04):46-49.
[52] Priyadarshani A. Insights of hypercarotenaemia: A brief review[J]. Clin Nutr ESPEN, 2018,23:19-24.DOI:10.1016/j.clnesp.2017.12.002.
[53] Kojima K. [Biophysical and Biochemical Research of Animal Rhodopsins][J]. Yakugaku Zasshi, 2021,141(10):1155-1160.DOI:10.1248/yakushi.21-00144.
[54] Chiu M, Dillon A, Watson S. Vitamin A deficiency and xerophthalmia in children of a developed country[J]. J Paediatr Child Health, 2016,52(7):699-703.DOI:10.1111/jpc.13243.
[55] Muller-Maatsch J, Sprenger J, Hempel J, et al. Carotenoids from gac fruit aril (Momordica cochinchinensis [Lour.] Spreng.) are more bioaccessible than those from carrot root and tomato fruit[J]. Food Res Int, 2017,99(Pt 2):928-935.DOI:10.1016/j.foodres.2016.10.053.
[56] Islam S N, Nusrat T, Begum P, et al. Carotenoids and beta-carotene in orange fleshed sweet potato: A possible solution to vitamin A deficiency[J]. Food Chem, 2016,199:628-631.DOI:10.1016/j.foodchem.2015.12.057.
[57] Wilson L M, Tharmarajah S, Jia Y, et al. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis[J]. Adv Nutr, 2021,12(6):2244-2254.DOI:10.1093/advances/nmab071.
[58] Youssef P N, Sheibani N, Albert D M. Retinal light toxicity[J]. Eye (Lond), 2011,25(1):1-14.DOI:10.1038/eye.2010.149.
[59] Tao J X, Zhou W C, Zhu X G. Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina[J]. Oxid Med Cell Longev, 2019,2019:6435364.DOI:10.1155/2019/6435364.
[60] Kijlstra A, Tian Y, Kelly E R, et al. Lutein: more than just a filter for blue light[J]. Prog Retin Eye Res, 2012,31(4):303-315.DOI:10.1016/j.preteyeres.2012.03.002.
[61] Widomska J, Gruszecki W I, Subczynski W K. Factors Differentiating the Antioxidant Activity of Macular Xanthophylls in the Human Eye Retina[J]. Antioxidants (Basel), 2021,10(4).DOI:10.3390/antiox10040601.
[62] Widomska J, Subczynski W K. Mechanisms enhancing the protective functions of macular xanthophylls in the retina during oxidative stress[J]. Experimental Eye Research, 2019,178:238-246.DOI:https://doi.org/10.1016/j.exer.2018.06.012.
[63] Frede K, Ebert F, Kipp A P, et al. Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells[J]. J Agric Food Chem, 2017,65(29):5944-5952.DOI:10.1021/acs.jafc.7b01929.
[64] Arunkumar R, Gorusupudi A, Li B, et al. Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4(-/-)/Bco2(-/-) double knockout mice[J]. Exp Eye Res, 2021,209:108680.DOI:10.1016/j.exer.2021.108680.
[65] Leung H H, Galano J M, Crauste C, et al. Combination of Lutein and Zeaxanthin, and DHA Regulated Polyunsaturated Fatty Acid Oxidation in H2O2-Stressed Retinal Cells[J]. Neurochem Res, 2020,45(5):1007-1019.DOI:10.1007/s11064-020-02994-4.
[66] Nidhi B, Sharavana G, Ramaprasad T R, et al. Lutein derived fragments exhibit higher antioxidant and anti-inflammatory properties than lutein in lipopolysaccharide induced inflammation in rats[J]. Food Funct, 2015,6(2):450-460.DOI:10.1039/c4fo00606b.
[67] Yang J, Li D, Zhang Y, et al. Lutein protected the retina from light induced retinal damage by inhibiting increasing oxidative stress and inflammation[J]. Journal of Functional Foods, 2020,73:104107.DOI:https://doi.org/10.1016/j.jff.2020.104107.
[68] Jin X H, Ohgami K, Shiratori K, et al. Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats[J]. Invest Ophthalmol Vis Sci, 2006,47(6):2562-2568.DOI:10.1167/iovs.05-1429.
[69] Gong X, Rubin L P. Role of macular xanthophylls in prevention of common neovascular retinopathies: retinopathy of prematurity and diabetic retinopathy[J]. Arch Biochem Biophys, 2015,572:40-48.DOI:10.1016/j.abb.2015.02.004.
[70] Yanai R, Chen S, Uchi S H, et al. Attenuation of choroidal neovascularization by dietary intake of omega-3 long-chain polyunsaturated fatty acids and lutein in mice[J]. PLoS One, 2018,13(4):e196037.DOI:10.1371/journal.pone.0196037.
[71] Ozawa Y, Sasaki M, Takahashi N, et al. Neuroprotective effects of lutein in the retina[J]. Curr Pharm Des, 2012,18(1):51-56.DOI:10.2174/138161212798919101.
[72] Bian Q, Qin T, Ren Z, et al. Lutein or zeaxanthin supplementation suppresses inflammatory responses in retinal pigment epithelial cells and macrophages[J]. Adv Exp Med Biol, 2012,723:43-50.DOI:10.1007/978-1-4614-0631-0_7.
[73] Padmanabha S, Vallikannan B. Fatty acids modulate the efficacy of lutein in cataract prevention: Assessment of oxidative and inflammatory parameters in rats[J]. Biochem Biophys Res Commun, 2018,500(2):435-442.DOI:10.1016/j.bbrc.2018.04.098.
[74] Shivarudrappa A H, Sharan K, Ponesakki G. Lutein activates downstream signaling pathways of unfolded protein response in hyperglycemic ARPE-19 cells[J]. Eur J Pharmacol, 2022,914:174663.DOI:10.1016/j.ejphar.2021.174663.
[75] Widjaja-Adhi M, Ramkumar S, von Lintig J. Protective role of carotenoids in the visual cycle[J]. FASEB J, 2018:j201800467R.DOI:10.1096/fj.201800467R.
[76] Meyer Z W V, Dietzel M, Zeimer M, et al. Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study[J]. Int J Retina Vitreous, 2016,2:14.DOI:10.1186/s40942-016-0039-6.
[77] Wilson L M, Tharmarajah S, Jia Y, et al. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis[J]. Adv Nutr, 2021,12(6):2244-2254.DOI:10.1093/advances/nmab071.
[78] Stringham J M, Stringham N T. Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation[J]. Exp Eye Res, 2016,151:1-8.DOI:10.1016/j.exer.2016.07.005.
[79] Huang Y M, Dou H L, Huang F F, et al. Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degeneration[J]. Biomed Res Int, 2015,2015:564738.DOI:10.1155/2015/564738.
[80] Wang X, Jiang C, Zhang Y, et al. Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trials[J]. Ophthalmic Res, 2014,52(4):198-205.DOI:10.1159/000363327.
[81] Liu R, Wang T, Zhang B, et al. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration[J]. Invest Ophthalmol Vis Sci, 2014,56(1):252-258.DOI:10.1167/iovs.14-15553.
[82] Chew E Y, Clemons T E, Sangiovanni J P, et al. Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3[J]. JAMA Ophthalmol, 2014,132(2):142-149.DOI:10.1001/jamaophthalmol.2013.7376.
[83] Arslan S, Kadayifcilar S, Samur G. The Potential Role of Dietary Antioxidant Capacity in Preventing Age-Related Macular Degeneration[J]. J Am Coll Nutr, 2019,38(5):424-432.DOI:10.1080/07315724.2018.1538830.
[84] Merle B, Cougnard-Gregoire A, Korobelnik J F, et al. Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study[J]. Nutrients, 2021,13(6).DOI:10.3390/nu13062047.
[85] Moeller S M, Parekh N, Tinker L, et al. Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative[J]. Arch Ophthalmol, 2006,124(8):1151-1162.DOI:10.1001/archopht.124.8.1151.
[86] Tan J S, Wang J J, Flood V, et al. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study[J]. Ophthalmology, 2008,115(2):334-341.DOI:10.1016/j.ophtha.2007.03.083.
[87] Wu J, Cho E, Willett W C, et al. Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up[J]. JAMA Ophthalmol, 2015,133(12):1415-1424.DOI:10.1001/jamaophthalmol.2015.3590.
[88] Garcia-Layana A, Recalde S, Hernandez M, et al. A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration[J]. Nutrients, 2021,13(4).DOI:10.3390/nu13041253.
[89] Ho L, van Leeuwen R, Witteman J C, et al. Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and omega-3 fatty acids: the Rotterdam study[J]. Arch Ophthalmol, 2011,129(6):758-766.DOI:10.1001/archophthalmol.2011.141.
[90] Peng J, Yuan J P, Wu C F, et al. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health[J]. Mar Drugs, 2011,9(10):1806-1828.DOI:10.3390/md9101806.
[91] Liu Y, Liu M, Zhang X, et al. Protective Effect of Fucoxanthin Isolated from Laminaria japonica against Visible Light-Induced Retinal Damage Both in Vitro and in Vivo[J]. J Agric Food Chem, 2016,64(2):416-424.DOI:10.1021/acs.jafc.5b05436.
[92] Liu Y, Guo Z, Wang S, et al. Fucoxanthin Pretreatment Ameliorates Visible Light-Induced Phagocytosis Disruption of RPE Cells under a Lipid-Rich Environment via the Nrf2 Pathway[J]. Mar Drugs, 2021,20(1).DOI:10.3390/md20010015.
[93] Chiang Y F, Chen H Y, Chang Y J, et al. Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells[J]. Antioxidants (Basel), 2020,9(12).DOI:10.3390/antiox9121176.
[94] Yuan J P, Peng J, Yin K, et al. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae[J]. Mol Nutr Food Res, 2011,55(1):150-165.DOI:10.1002/mnfr.201000414.
[95] Ambati R R, Phang S M, Ravi S, et al. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review[J]. Mar Drugs, 2014,12(1):128-152.DOI:10.3390/md12010128.
[96] Lin C W, Yang C M, Yang C H. Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model[J]. Mar Drugs, 2020,18(8).DOI:10.3390/md18080387.
[97] Otsuka T, Shimazawa M, Inoue Y, et al. Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models[J]. Curr Eye Res, 2016,41(11):1465-1472.DOI:10.3109/02713683.2015.1127392.
[98] Fakhri S, Abbaszadeh F, Dargahi L, et al. Astaxanthin: A mechanistic review on its biological activities and health benefits[J]. Pharmacol Res, 2018,136:1-20.DOI:10.1016/j.phrs.2018.08.012.
[99] Janani R, Anitha R E, Perumal M K, et al. Astaxanthin mediated regulation of VEGF through HIF1alpha and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model[J]. Exp Eye Res, 2021,206:108555.DOI:10.1016/j.exer.2021.108555.
[100] Igwe E O, Charlton K E, Probst Y C. Usual dietary anthocyanin intake, sources and their association with blood pressure in a representative sample of Australian adults[J]. J Hum Nutr Diet, 2019,32(5):578-590.DOI:10.1111/jhn.12647.
[101] Nomi Y, Iwasaki-Kurashige K, Matsumoto H. Therapeutic Effects of Anthocyanins for Vision and Eye Health[J]. Molecules, 2019,24(18).DOI:10.3390/molecules24183311.
[102] Yanamala N, Tirupula K C, Balem F, et al. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 1. Structural aspects[J]. Photochem Photobiol, 2009,85(2):454-462.DOI:10.1111/j.1751-1097.2008.00517.x.
[103] Tirupula K C, Balem F, Yanamala N, et al. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects[J]. Photochem Photobiol, 2009,85(2):463-470.DOI:10.1111/j.1751-1097.2008.00533.x.
[104] Song Y, Huang L, Yu J. Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling[J]. J Neuroimmunol, 2016,301:1-6.DOI:10.1016/j.jneuroim.2016.11.001.
[105] Wang Y, Huo Y, Zhao L, et al. Cyanidin-3-glucoside and its phenolic acid metabolites attenuate visible light-induced retinal degeneration in vivo via activation of Nrf2/HO-1 pathway and NF-kappaB suppression[J]. Mol Nutr Food Res, 2016,60(7):1564-1577.DOI:10.1002/mnfr.201501048.
[106] Lee B L, Kang J H, Kim H M, et al. Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light in A2E-laden ARPE19 cell cultures and mice[J]. Nutr Res, 2016,36(12):1402-1414.DOI:10.1016/j.nutres.2016.11.008.
[107] Jin X, Wang C, Wu W, et al. Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells[J]. J Immunol Res, 2018,2018:5604610.DOI:10.1155/2018/5604610.
[108] Huang W, Yan Z, Li D, et al. Antioxidant and Anti-Inflammatory Effects of Blueberry Anthocyanins on High Glucose-Induced Human Retinal Capillary Endothelial Cells[J]. Oxid Med Cell Longev, 2018,2018:1862462.DOI:10.1155/2018/1862462.
[109] Miyake S, Takahashi N, Sasaki M, et al. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism[J]. Lab Invest, 2012,92(1):102-109.DOI:10.1038/labinvest.2011.132.
[110] Ooe E, Kuse Y, Yako T, et al. Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line[J]. Mol Vis, 2018,24:621-632.
[111] Peng W, Wu Y, Peng Z, et al. Cyanidin-3-glucoside improves the barrier function of retinal pigment epithelium cells by attenuating endoplasmic reticulum stress-induced apoptosis[J]. Food Research International, 2022,157:111313.DOI:https://doi.org/10.1016/j.foodres.2022.111313.
[112] Nakamura O, Moritoh S, Sato K, et al. Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress[J]. Clin Ophthalmol, 2017,11:1825-1834.DOI:10.2147/OPTH.S145159.
[113] Simon M V, Agnolazza D L, German O L, et al. Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress[J]. J Neurochem, 2016,136(5):931-946.DOI:10.1111/jnc.13487.
[114] Chong E W, Kreis A J, Wong T Y, et al. Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis[J]. Arch Ophthalmol, 2008,126(6):826-833.DOI:10.1001/archopht.126.6.826.
[115] Gorusupudi A, Rallabandi R, Li B, et al. Retinal bioavailability and functional effects of a synthetic very-long-chain polyunsaturated fatty acid in mice[J]. Proc Natl Acad Sci U S A, 2021,118(6).DOI:10.1073/pnas.2017739118.
[116] Deng Q, Wang Y, Wang C, et al. Dietary supplementation with omega-3 polyunsaturated fatty acid-rich oils protects against visible-light-induced retinal damage in vivo[J]. Food Funct, 2018,9(4):2469-2479.DOI:10.1039/c7fo01168g.
[117] Cortina M S, Bazan H E. Docosahexaenoic acid, protectins and dry eye[J]. Curr Opin Clin Nutr Metab Care, 2011,14(2):132-137.DOI:10.1097/MCO.0b013e328342bb1a.
[118] Liu Y, Zhang D, Wu Y, et al. Docosahexaenoic acid aggravates photooxidative damage in retinal pigment epithelial cells via lipid peroxidation[J]. J Photochem Photobiol B, 2014,140:85-93.DOI:10.1016/j.jphotobiol.2014.07.016.
[119] Chao J R, Knight K, Engel A L, et al. Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side[J]. J Biol Chem, 2017,292(31):12895-12905.DOI:10.1074/jbc.M117.788422.
[120] Gaucher D, Arnault E, Husson Z, et al. Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cells[J]. Amino Acids, 2012,43(5):1979-1993.DOI:10.1007/s00726-012-1273-3.
[121] Garcia-Ayuso D, Di Pierdomenico J, Hadj-Said W, et al. Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration[J]. Invest Ophthalmol Vis Sci, 2018,59(3):1396-1409.DOI:10.1167/iovs.17-23258.
[122] Froger N, Cadetti L, Lorach H, et al. Taurine provides neuroprotection against retinal ganglion cell degeneration[J]. PLoS One, 2012,7(10):e42017.DOI:10.1371/journal.pone.0042017.
[123] Tao Y, He M, Yang Q, et al. Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments[J]. Drug Des Devel Ther, 2019,13:2689-2702.DOI:10.2147/DDDT.S194169.
[124] Schwartz S G, Wang X, Chavis P, et al. Vitamin A and fish oils for preventing the progression of retinitis pigmentosa[J]. Cochrane Database Syst Rev, 2020,6:D8428.DOI:10.1002/14651858.CD008428.pub3.
[125] Biousse V, Newman N J. Diagnosis and clinical features of common optic neuropathies[J]. Lancet Neurol, 2016,15(13):1355-1367.DOI:10.1016/S1474-4422(16)30237-X.
[126] 陈子畅, 樊芯, 李晓燕, 等. 维生素A对光损伤小鼠视网膜功能和结构的保护作用[J]. 宁夏医科大学学报, 2016,38(07):750-754.
[127] Gaby A R. Nutritional therapies for ocular disorders: Part Three[J]. Altern Med Rev, 2008,13(3):191-204.
[128] Ravindran R D, Vashist P, Gupta S K, et al. Inverse association of vitamin C with cataract in older people in India[J]. Ophthalmology, 2011,118(10):1958-1965.DOI:10.1016/j.ophtha.2011.03.016.