Advance of the effect of β-nicotinamide single nucleotide on physiological function

Abstract

Abstract: The overweight or obese population in sub-health status and the aging population in China are increasing year by year. The cellular level of nicotinamide adenine dinucleotide (NAD+) decreases dramatically with the process of aging and obesity. NAD+ is the key target of cellular energy metabolism, regulating cell function and delaying senescent process . Therefore, it has become a research highlight to improve physiological function and delay aging by supplementing NAD precursors. β-Nicotinamide mononucleotide (NMN) is an intermediate product of NAD+ metabolism in animals, and it is also the most direct and efficient NAD+ supplement precursor at present. However, NMN has complex effects on different organs in many aspects of physiological function, and the results of animal tests are not consistent with human tests , and the dosage has not been determined. This paper summarizes the recent results of NMN animal and human experiments, aiming to explore the effects, mechanisms, doses and adverse reactions of NMN supplementation on animal and human physiological functions, and provide ideas for future researches and application of NMN.

Key words: β-nicotinamide mononucleotide（NMN）, Nicotinamide adenine dinucleotide（NAD） metabolism, Animal experiments, Human clinical trials, Physiological function

CLC Number:

Tao Chen. Advance of the effect of β-nicotinamide single nucleotide on physiological function [J]. FOOD SCIENCE, 0, (): 0-0.

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