Research progress on the function and application of sweet tea and its active ingredients

Abstract

Abstract: Sweet tea is a sweet plant that integrates the three flavors of tea sugar medicine, is rich in bioactive components, including rubusoside, polyphenols, polysaccharides and amino acids. It has many active functions such as anti-oxidation aging, lowering blood sugar and blood lipid, antibacterial and anti-allergic, anticancer and anti-tumor, etc. It has great potential in promoting public health and promoting food industry. This paper summarizes the extraction methods, health effects and application of different active components of sweet tea, and puts forward the challenges of current research and future research directions, which provides more valuable references for the development and utilization of sweet tea.

Key words: Sweet tea, Active components, Biological activity, Application research

CLC Number:

TS202.1

Zhi ying HE. Research progress on the function and application of sweet tea and its active ingredients[J]. FOOD SCIENCE.

References

[1]韩碧群, 谭芳, 张鑫瑶, 等.甜茶的应用历史与研究现状[J].中国现代中药, 2014, 16(07):582-587 [2]李树刚.甜茶, 悬钩子属一新种[J].广西植物, 1981, (4):17-19 [3]韦家福, 黄燮才.广西甜茶原植物的鉴定[J].中药材, 1996, (01):16-17 [4]李荫昆, 黄定中.甜茶的生物学研究初报[J].广西植物, 1981, (04):21-24 [5]雷鸣, 徐应淑, 徐凡, 等.多穗石柯化学成分及药理作用研究进展[J].中药药理与临床, 2017, 33(06):176-180 [6]He X Q, Liu D, Liu H Y, et al.Prevention of ulcerative colitis in mice by sweet tea (Lithocarpus litseifolius) via the regulation of gut microbiota and butyric-acid-mediated anti-inflammatory signaling[J].Nutrients, 2022, 14(11):2208-2208 [7]Jia Z, Xie Y, Wu H, et al.Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2STAT3 signaling pathway[J].Oncology reports, 2021, 46(1):1-12 [8] Zhou CaiJie Z C J, Huang Song H S, Liu JiangQi L J Q, et al.Sweet tea leaves extract improves leptin resistance in diet-induced obese rats[J]. 2013.[J].民族药理学杂志, 2013, 145(01):386-32 [9]朱苗, 朱成成, 吴慧琳, 等.石阡野生甜茶营养成分及其抗氧化活性研究[J].粮食与油脂, 2019, 32(09):89-91 [10]杨大坚, 钟炽昌, 肖倬殷.甜茶化学成分研究Ⅰ甜味成分[J].中草药, 1991, 22(03):99-101 [11]谭家忠, 廖娜, 张宝堂, 等.天然甜味剂的开发应用及展望[J].中国食品添加剂, 2022, 33(01):32-39 [12]周峰, 柯家平, 姜宗德, 等.茶叶滋味成分研究进展[J].中国茶叶加工, 2023, (04):15-21 [13]Li J, Yao Y, Wang J, et al.Rutin, γ-Aminobutyric Acid, Gallic Acid, and Caffeine Negatively Affect the Sweet-Mellow Taste of Congou Black Tea Infusions[J].molecules, 2019, 24(23):4221-4221 [14]姚佳, 陈开琴, 何志云, 等.野生甜茶中氨基酸成分分析及营养评价[J].生物化工, 2021, 7(04):78-81 [15]徐珊珊, 史星雲, 李强, 等.不同柽柳游离氨基酸组成及含量分析[J].林业科技通讯, 2023, (09):63-67 [16]张健, 侴桂新, 章苏宁, 等.甜茶叶中甜茶苷的-分析[J].光谱实验室, 2011, 28(05):2692-2696 [17]]黎四芳著.高甜度甜味剂的生产与应用 [18]刘英, 郭洋洋, 徐永莉, 等.响应面法优化甜茶苷的超声提取工艺[J].化学与生物工程, 2023, 40(10):34-38 [19]向锋, 董新荣, 曾建国.甜茶苷和甜茶多酚同时提取工艺优化[J].食品工业科技, 2019, 40(06):173-178 [20]Ko J-A, Kim Y-M, Ryu Y B, et al.Mass Production of Rubusoside Using a Novel Stevioside-Specific β-Glucosidase from Aspergillus aculeatus[J].Journal of agricultural and food chemistry, 2012, 60(24):6210-6216 [21]肖敏, 阎振鑫, 徐莉.一株高效转化甜菊苷为甜茶苷的菌株及其培养方法与应用[P].山东省:CN202010850900.0, 2022-10-25. [22]Meng T, Zhang Y, Huang J, et al.Rubusoside mitigates neuroinflammation and cellular apoptosis in Parkinson' s disease, and alters gut microbiota and metabolite composition[J].Phytomedicine, 2024, 124:155309-155309 [23]田翠平, 瞿伟菁, 孙斌, 等.甜茶素提取物对致高血糖大鼠的降血糖作用研究[J].营养学报, 2003, 25(1):29-33 [24]Xi-yu Hu, Ying Chang, Zheng-zhe Xu, et al.Rubusoside Reduces Blood Glucose and Inhibits Oxidative Stress by Activating the AMPK Signaling Pathway in Type 2 Diabetes Mellitus Mice. [J].Natural Product Communications, 2022, 17(1):- [25]谢莹, 陈全斌, 罗达伟, 等.高纯度甜茶甙对四氧嘧啶致糖尿病小鼠血糖的影响[J].陕西中医, 2010, 31(03):367-368 [26]左玉.多酚类化合物研究进展[J].粮食与油脂, 2013, 26(04):6-10 [27]陈俊婕, 劳颖仪, 陈晓维, 等.茶多酚的功能活性及稳态化研究进展[J].中国果菜, 2024, 44(08):25-31 [28]张桂玲, 温四民.甜味植物研究进展[J].安徽农业科学, 2006, (18):4712-4713 [29]李娟, 牟小凤.热浸提法提取茶叶中茶多酚的方法优化[J].绵阳师范学院学报, 2022, 41(02):50-55 [30]高程海, 滕建文, 韦保耀, 等.广西甜茶多酚提取工艺研究[J].食品工业科技, 2006, (04):133-138 [31]程雅芳, 杨洋, 温富雄, 等.响应面分析法优化酶提取甜茶茶多酚工艺[J].食品科学, 2012, 33(10):10-15 [32]林继元, 方北曙.从广西甜茶素粗提物脱苦残渣中提取甜茶茶多酚的研究[J].安徽农业科学, 2007, (20):6157-6159 [33]Ouyang S, Lu P, Li J, et al.Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation[J].Respiratory Research, 2024, 25(1):311- [34]Song Z, Ho C T, Zhang X.Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder[J].Journal of Agricultural and Food Chemistry, 2024, 72(21):12184-12197 [35]王硕, 侯小利, 周小雷, 等.甜茶多酚对高脂血症大鼠的降血脂作用及其机制研究[J].中国药学杂志, 2015, 50(20):1811-1815 [36]郑丽静, 岳焕芳, 赵立群, 等.茶多酚在鲜切脆山药块加工中的应用效果[J].中国瓜菜, 2024, 37(10):156-162 [37]葛天睿, 黄雪君, 张娜, 等.茶多酚在医药和食品领域的应用研究进展[J].食品安全质量检测学报, 2024, 15(17):176-184 [38]刘春朋, 郑钊武, 曾玉慧, 等.无抗饲粮中添加茶多酚对仔猪生长性能?血清生化指标及抗氧化能力的影响[J].中国畜牧杂志, 2023, 59(08):334-338 [39]付晶, 梁玉文, 刘旭霞, 等.种鹅饲粮添加茶多酚对1日龄雏鹅抗氧化能力和血清生化指标的影响[J].饲料博览, 2023, (02):7-12+35 [40]陈全斌, 谭冬明, 李佳, 等.甜茶植株不同部位总黄酮含量的测定[J].林业科技, 2007, (04):68-70 [41]吴家超, 李水萍, 张永怡, 等.民族药甜茶化学成分与药理作用研究进展[J].中华中医药杂志, 2021, 36(06):3504-3508 [42]Liu H Y, Liu Y, Mai Y H, et al.Phenolic Content, Main Flavonoids, and Antioxidant Capacity of Instant Sweet Tea (Lithocarpus litseifolius [Hance] Chun) Prepared with Different Raw Materials and Drying Methods[J].Foods, 2021, 10(8):1930-1930 [43]程雅芳, 杨洋, 韦银凤, 等.超声波辅助提取甜茶黄酮的工艺优化[J].食品科技, 2011, 36(04):189-193 [44]Wang H, Yang H, Nie S, et al.Efficient extraction of flavonoid compounds in sweet tea (Lithocarpus litseifolius (Hance) Chun) via ultrasonic-natural deep eutectic solvent composite approach based on machine learning[J].Industrial Crops and Products, 2024, 215:118434-118434 [45]里雨桐, 朱成豪, 唐健民, 等.响应面法优化广西甜茶总黄酮提取工艺及抗氧化活性研究[J].食品科技, 2019, 44(11):245-251 [46]王赛男, 陈丹妮, 胡克坚, 等.穇子总黄酮成分及其对秀丽隐杆线虫的抗衰老作用[J].食品科学, 2024, 45(14):94-102 [47]Hao B C, Yang Z, Liu H Y, et al.Advances in Flavonoid Research: Sources,Biological Activities,and Developmental Prospectives[J].CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46(4):2884-2925 [48]吕芳, 李卫萍, 田朝霞, 等.木犀草素通过调控通路改善慢性心力衰竭大鼠心脏功能及心肌纤维化的研究[J].免疫学杂志, 2022, 38(05):407-415 [49]Liga S, Paul C, Péter F.Flavonoids: Overview of Biosynthesis, Biological Activity, and Current Extraction Techniques[J].Plants, 2023, 12(14):2732-2732 [50]Guo H, Fu M X, Zhao Y X, et al.The Chemical, Structural, and Biological Properties of Crude Polysaccharides from Sweet Tea (Lithocarpus litseifolius (Hance) Chun) Based on Different Extraction Technologies.[J].FOODS, 2021, 10:1779-1779 [51]Liu Y, Liu H Y, Xia Y, et al.Screening and process optimization of ultrasound-assisted extraction of main antioxidants from sweet tea (Lithocarpus litseifolius [Hance] Chun). [J].Food Bioscience, 2021, 43(0):101277-10277 [52]Tian Z X, Tan Z F, Li Y J, et al.Rapid monitoring of flavonoid content in sweet tea (Lithocarpus litseifolius (Hance) Chun) leaves using NIR spectroscopy[J].Plant Methods, 2022, 18(1):44- [53]茹琪, 金蒙, 苏远, 等.黄酮类化合物协同增效作用研究进展[J].天然产物研究与开发, 2023, 35(03):531-538 [54]赖建平, 顾采琴, 朱冬雪, 等.香蕉果皮黄酮及与丙酸、茶多酚复配剂的抑菌防腐作用[J].食品科学, 2012, 33(13):53-57 [55]Zhao C F, Lei D J, Song G H, et al.Characterisation of water-soluble proanthocyanidins of Pyracantha fortuneana fruit and their improvement in cell bioavailable antioxidant activity of quercetin[J].Food Chemistry, 2015, 169:484-491 [56]Dyachenko E I, Bel’skaya L V.The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review[J].Metabolites, 2023, 14(1):28- [57]Sukhotnik I, Khateeb K, Mogilner J G.Dietary Glutamine Supplementation Prevents Mucosal Injury and Modulates Intestinal Epithelial Restitution Following Ischemia-Reperfusion Injury in the Rat[J].Dig Dis Sci, 2007, 52(6):1497-502 [58]梁小庆, 石涛, 谢培, 等.甜茶素对四氧嘧啶糖尿病大鼠血糖的影响[J].中外医疗, 2008, 27(35):7-8 [59]杨淑银, 岳二丽, 郭留云, 陆珂, 杨梦宇.甜茶甙对口腔变异链球菌生长及致龋性影响的实验研究[J].新中医, 2023, 55(7):9-14 [60]王瑶, 陈依军, 吴旭日.甜茶苷的酶法糖基化修饰进展[J].药物生物技术, 2019, 26(04):337-342 [61]滕建文, 黄丽, 易湘茜, 夏宁, 韦保耀.广西甜茶多酚的抗过敏性评价[J].食品与机械, 2008, 24(5):48-51 [62]吴航, 许婧.茶多酚的生物学功能及其在动物生产中的应用[J].饲料研究, 2024, 47(6):165-168 [63]张德福, 闫天慧, 励建荣, 等.茶多酚对嗜水气单胞菌致病力的抑制作用[J].中国食品学报, 2024, 24(01):21-30 [64]Song J, Feng H, Wu M, et al.Development of a bioactive chitosan HPMC-based membrane with tea polyphenols encapsulated in β-cyclodextrin as an effective enhancement[J].Materials Today Communications, 2021, 27:102324-102324 [65]刘韫滔, 黄伟民, 李诚, 等.木姜叶柯全发酵茶的活性成分及其降血糖活性研究[J].食品与发酵工业, 2020, 46(20):53-60 [66]黄荣岗, 杨家庆, 何家靖, 等.广西甜茶提取物体内抗肿瘤实验研究初探[J].广东药学院学报, 2012, 28(02):173-175 [67]四川省中药研究所编.四川常用中草药[M]. 成都:四川人民出版社, 1971.09. [68]郭瑞静.缙云甜茶的历史内涵与经济价值[J].现代商业, 2012, (17):178-179 [69]刘延昌.甜茶护齿含片对口腔4种常居菌的体外实验研究[D].广西医科大学, 2012. [70]《浙江药用植物志》编写组.浙江药用植物志上[M]. 杭州:浙江科学技术出版社, 1980.07. [71]《四川中药志》协作编写组编.四川中药志第1卷[M]. 成都:四川人民出版社, 1979.12. [72]吴婕, 宫江宁.大孔树脂纯化甜茶多酚及其对α-葡萄糖苷酶抑制活性和·抗氧化性的研究[J].中国农业科技导报, 2021, 23(06):113-119 [73]Li N, Li X, Shi Y L, et al.Trilobatin, a component from Lithocarpus polystachyrus Rehd., increases longevity in C. elegans through activating SKN1/SIRT3/DAF16 signaling pathway[J].Frontiers in Pharmacology, 2021, 12:655045- [74]Xiao R, Wei Y, Zhang Y, et al.Trilobatin, a naturally occurring food additive, ameliorates exhaustive exercise-induced fatigue in mice: involvement of Nrf2/ARE/ferroptosis signaling pathway[J].Frontiers in Pharmacology, 2022, 13:913367-913367 [75]Gao J, Xu Y, Zhang J, et al.Lithocarpus polystachyus Rehdleaves aqueous extract protects against hydrogen peroxide induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway[J].International Journal of Molecular Medicine, 2018, 42(6):3485-3494 [76]郝辉, 龚梅秋, 刘远上, 等.甜茶多糖的提取?羧甲基化修饰及抗氧化活性研究[J].陕西农业科学, 2022, 68(11):37-42 [77]徐位坤, 孟丽珊, 石虹.从悬钩子叶中提取甜茶素[J].植物杂志, 1980, (04):10-10 [78]Su Chengfu, Yang Chuanbin, Gong Man, et al.Antidiabetic Activity and Potential Mechanism of Amentoflavone in Diabetic Mice.[J].Molecules, 2019, 24(11):- [79]邢明霞, 谢凡, 艾连中.滇橄榄鲜果中多酚提取物的降血糖机制研究[J].食品与发酵科技, 2023, 59(02):1-11 [80]Luo K, Ma C, Xing S, et al.White tea and its active polyphenols lower cholesterol through reduction of very-low-density lipoprotein production and induction of LDLR expression[J].Biomedicine & Pharmacotherapy, 2020, 127:110146-110146 [81]Zhou J, Tang L, Shen C L, et al.Green tea polyphenols modify gut-microbiota dependent metabolisms of energy, bile constituents and micronutrients in female Sprague–Dawley rats[J].The Journal of nutritional biochemistry, 2018, 61:68-81 [82]李军民, 牛恒立, 谢明全, 等.山楂黄酮抗动脉粥样硬化及降血脂作用机制研究[J].中国临床药理学与治疗学, 2023, 28(03):276-282 [83]赫亮, 姚佳琪, 刘怡菲, 祝儒刚, 陈罡, 马妍.软枣猕猴桃黄酮降血糖作用研究[J]..辽宁林业科技, 2024, (1):8-11 [84]Wang H, Li H, Hou Y, et al.Plant polysaccharides: Sources, structures, and antidiabetic effects[J].Current Opinion in Food Science, 2023, 51: 101013- 101013 [85]黄丽微, 何克新.甜茶甙和木糖醇对变形链球菌合成水不溶性胞外多糖的对比研究[J].广西医学, 2010, 32(03):265-266 [86]何克新, 黄丽微, 陈文霞, 等.甜茶甙对变形链球菌葡糖基转移酶的影响[J].广东牙病防治, 2010, 18(05):230-233 [87]Guan C, Che F, Zhou H, et al.Effect of rubusoside,a natural sucrose substitute,on Streptococcus mutans biofilm cariogenic potential and virulence gene expression in vitro[J].Applied and Environmental Microbiology, 2020, 86(16):e01012-20 [88]Leyva-López N, Gutierrez-Grijalva E P, Ambriz-Perez D L, et al.Flavonoids as cytokine modulators: a possible therapy for inflammation-related diseases[J].International journal of molecular sciences, 2016, 17(6):921- [89]Wang S, Wuniqiemu T, Tang W, et al.Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex[J].International immunopharmacology, 2021, 94:107460-107460 [90]Zhang X, Zhang B, Zhang P, et al.Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873CDK3 in breast cancer cells[J].PLoS One, 2019, 14(5):e0217181- [91]Shang A, Liu H Y, Luo M, et al.Sweet tea (Lithocarpus polystachyus rehd) as a new natural source of bioactive dihydrochalcones with multiple health benefits[J].Critical Reviews in Food Science and Nutrition, 2022, 62(4):917-934 [92]黄荣岗, 杨家庆, 何家靖, 等.广西甜茶提取物体内抗肿瘤实验研究初探[J].广东药学院学报, 2012, 28(02):173-175 [93]Liu Yuanyuan, Fan Chenghe, Pu Lv, et al.Phloretin induces cell cycle arrest and apoptosis of human glioblastoma cells through the generation of reactive oxygen species[J].Journal of Neuro-Oncology, 2016, 128(2):217-223 [94]张月月, 王君明, 崔瑛.雷公藤红素联合槲皮素体外抗癌增效作用[J].中国老年学杂志, 2023, 43(19):4757-4759 [95]Jia Z, Xie Y, Wu H, et al.Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2STAT3 signaling pathway[J].Oncology reports, 2021, 46(1):1-12 [96]Zhang H, Qi R, Zeng Y, et al.Chinese Sweet Leaf Tea (Rubus suavissimus) Mitigates LPS-Induced Low-Grade Chronic Inflammation and Reduces the Risk of Metabolic Disorders in a C57BL6J Mouse Model[J].Journal of agricultural and food chemistry, 2020, 68(1):138-146 [97]Kamdi S P, Raval A, Nakhate K T.Phloridzin attenuates lipopolysaccharide-induced cognitive impairment via antioxidant, anti-inflammatory and neuromodulatory activities[J].Cytokine, 2021, 139:155408-155408 [98]廖晓峰.从多穗柯叶中提取多穗柯棕色素的研究[J].华东地质学院学报, 1998, (02):58-63 [99]Zhou C J, Huang S, Liu J Q, et al.Sweet tea leaves extract improves leptin resistance in diet-induced obese rats[J].Journal of Ethnopharmacology, 2013, 145(1):386-392 [100]蒋荣华, 候小利, 王硕, 等.甜茶多酚对自发性高血压大鼠的影响[J].世界科学技术-中医药现代化, 2015, 17(07):1479-1485 [101]钟正贤, 周桂芬, 陈学芬, 等.广西甜茶提取物药理研究[J].时珍国医国药, 2000, (10):867-868 [102]柳俊辉, 周小雷, 翁铭钻, 等.广西甜茶多酚对四氧嘧啶致糖尿病小鼠的降血糖作用[J].中药药理与临床, 2014, 30(06):51-54 [103]李雅晶, 胡其英, 叶素丹.山蜡梅叶复合茶饮品的配方与加工工艺研究[J].现代农业科技, 2014, (24):283-284 [104]陈碧, 李炉娟, 郭松, 等.甜香型甘蔗甜茶酒发酵工艺优化及品质分析[J].中国酿造, 2023, 42(12):212-218 [105]林继元, 饶力群.甜茶酸奶的研制[J].食品与机械, 2006, (05):106-108 [106]何玲玲, 倪团结, 杨东妮.甜茶低糖保健果冻的研制[J].现代食品, 2021, (17):93-97+101 [107]李雨嫣.甜茶素干预糖尿病机理研究及产品开发[D].湖南农业大学, 2019.DOI:10.27136/d.cnki.ghunu.2019.000325. [108]王超, 益西多吉, 索朗德吉.姜汁甜茶的开发[J].饮料工业, 2014, 17(08):12-14 [109]郭春雨, 胡启明, 邓慧群, 等.广西甜茶悬钩子不同加工工艺感官品质分析[J].南方园艺, 2023, 34(05):72-76 [110]黄佩芳, 蒋世琼.甜茶的综合开发[J].广西化工, 2002, (02):24-25