Gut Microbiota and Functional Constipation: Recent Advances in Pathogenesis and Nutritional Interventions

doi:10.7506/spkx1002-6630-20241219-163

FOOD SCIENCE ›› 2025, Vol. 46 ›› Issue (16): 13-24.doi: 10.7506/spkx1002-6630-20241219-163

• Prevent Constipation and Promote Intestinal Health • Previous Articles

Gut Microbiota and Functional Constipation: Recent Advances in Pathogenesis and Nutritional Interventions

DUAN Hao, LIU Gaigai, LU Jiamin, LI Yang, CHANG Xinyue, YANG Tianyu, BAO Shuyuan, SONG Wei, YAN Wenjie

(1. Beijing Key Laboratory of Bioactive Substances and Functional Food, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China; 2. Functional Inspection Center of Health Food, College of Applied Sciences and Humanities, Beijing Union University, Beijing 100191, China; 3. Xiangya School of Public Health, Central South University, Changsha 410083, China)

Published:2025-07-22

Abstract

Abstract: With the acceleration of population aging, the problem of functional constipation has become increasingly prominent, significantly affecting the quality of life of the elderly. Currently, there are numerous studies focusing on the pathogenesis of and nutritional interventions in functional constipation in the elderly population. However, systematic reviews are lacking. Therefore, this paper focuses on discussing the correlation between gut microbial metabolites and the occurrence of functional constipation, and presents a systematic summary and classification of the raw materials that have been approved for use in health foods for moistening the intestine and promoting defecation. Furthermore, their mechanisms of action in alleviating constipation are discussed. This review is expected to provide enlightenment and assistance for the research and development of functional foods against functional constipation in the elderly.

Key words: elderly; functional constipation; gut microbiota metabolites; mechanism of action; raw materials; health foods

CLC Number:

TS218

DUAN Hao, LIU Gaigai, LU Jiamin, LI Yang, CHANG Xinyue, YANG Tianyu, BAO Shuyuan, SONG Wei, YAN Wenjie. Gut Microbiota and Functional Constipation: Recent Advances in Pathogenesis and Nutritional Interventions[J]. FOOD SCIENCE, 2025, 46(16): 13-24.

[1]	ZHANG Shaoshi, ZHAO Jian, GUO Yu, YAN Wenjie. Recent Progress in the Application of Organoid Technology in the Field of Health Foods [J]. FOOD SCIENCE, 2025, 46(14): 357-346.
[2]	Mei-Yan LI Xiao-dan WANG linling li 举扬石. Research progress on the application of molecular fishing technology in the field of medicine and food homology [J]. FOOD SCIENCE, 0, (): 0-0.
[3]	HU Ge, QIN Fei, CAO Jianmin, JI Zhe, ZHOU Qiyun, ZHOU Haitao. Curcumin Combined with Aerobic Exercise Improved Liver Function in Rats with Non-alcoholic Fatty Liver Disease [J]. FOOD SCIENCE, 2025, 46(10): 178-187.
[4]	. Application prospect of organoid technology in the field of health food [J]. FOOD SCIENCE, 0, (): 0-0.
[5]	WANG Diandian, ZHOU Yaxi, WANG Xianchun, DUAN Hao, GUO Jinhong, ZHENG Yue, YAN Wenjie. Functions of Whey Protein and Its Applications in Functional Foods [J]. FOOD SCIENCE, 2024, 45(19): 304-316.
[6]	Ya-Xi ZHOU. Functions of whey proteins and their applications in functional foods [J]. FOOD SCIENCE, 0, (): 0-0.
[7]	. Improvement of curcumin combined with aerobic exercise on liver function in rats with non-alcoholic fatty liver disease [J]. FOOD SCIENCE, 0, (): 0-0.
[8]	DUAN Hao, SONG Wei, WANG Feng, YAN Wenjie. Advances in the Application of Carotenoids in Health Foods for Relieving Visual Fatigue [J]. FOOD SCIENCE, 2024, 45(6): 317-325.
[9]	. Advances in the application of carotenoid raw materials in health foods for the relief of visual fatigue [J]. FOOD SCIENCE, 0, (): 0-0.
[10]	Wei-Zhu CHEN hui CHEN Yi Zhang. Anti-Inflammatory and Hypoglycemic Activities of Polyphenols from Sargassum horneri in Vitro [J]. FOOD SCIENCE, 0, (): 0-0.
[11]	Hui Sun Xiao Lei Li. Study on Terpenes and Cannabinoids in Hemp Oil Based on GC-MS and UPLC [J]. FOOD SCIENCE, 0, (): 0-0.
[12]	ZHANG Ruiting, CAI Youxi, ZHANG Hao, SUN Hui, SUN Xiaodong, TENG Yajun, LI Xiaolei. Analysis of Terpenes and Cannabinoids in Hemp Oil by Gas Chromatography-Mass Spectrometry and Ultra-high Performance Liquid Chromatography [J]. FOOD SCIENCE, 2024, 45(1): 150-157.
[13]	Wenni TIAN Jie ，XIAO. Modulation Effects of Beeswax Content on the Digestive Release Profile and Macrophage Uptake Efficiency of Nanostructured Lipid Carriers [J]. FOOD SCIENCE, 0, (): 0-0.
[14]	. Selenization Modification and Physicochemical Structural Characterization of Polysaccharides from Perilla frutescens L. [J]. FOOD SCIENCE, 0, (): 0-0.
[15]	ZHAO Yana, GUO Jiangtao, ZHOU Tiantian, LI Menghao, LI Huizhen. Selenization Modification and Physicochemical and Structural Characterization of Polysaccharides from Perilla frutescens L. Leaves [J]. FOOD SCIENCE, 2023, 44(20): 94-99.

Gut Microbiota and Functional Constipation: Recent Advances in Pathogenesis and Nutritional Interventions

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments