Abstract: Eye health has become an important part of national health. With the improvement of public health conditions, visual fatigue has become a focus of attention in eye health. In this context, functional foods have played a key role in maintaining visual fatigue. However, there are challenges in evaluating the efficacy of functional foods in relieving visual fatigue, including a lack of data from animal experiments and the subjectivity of human feeding trials. This paper analyzes the current development status of functional foods for eye health, the various symptoms of visual fatigue, and their association with visual organ. It explores the significant advantages of 3D tissue-engineered organoid technology in simulating the structure and function of the eye, and its potential application in establishing visual fatigue models and exploring the mechanisms of nutrient interventions. Finally, based on organoid technology and existing technical bottlenecks combined with the current policy orientation, new suggestions are made for the evaluation system for and efficacy claims on eye health-related functional foods. This article provides a new research direction for developing more effective eye health-protecting functional foods and highlights the important role of organoid technology in driving the development of eye health-protecting functional foods.

Key words: visual fatigue; organoid technology; health foods; efficacy claims