Abstract: Objective: In order to alleviate glucose and lipid metabolism disorders from obesity and related chronic diseases while considering the side effects of weight-loss drugs or surgery, a vinegar beverage with ameliorative effect on obesity-induced glucose and lipid metabolism disorders was developed using Gastrodia elata, which has recently been listed as a substance that than traditionally serves as both food and medicinal material. Methods: Based on general physiological indexes, pathological sections of liver and adipocytes, and glucose and lipid metabolism indexes, the alleviating effect of G. elata vinegar on obesity-induced glucose and lipid metabolism disorders in mice fed a high-sugar and high-fat diet. Results: G. elata vinegar effectively reduced body mass in obese mice. Compared with the model group, the Lee’s index, body fat percentage, liver mass, fasting blood glucose level, area under the curve (AUC) of blood glucose, total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) were reduced in the vinegar-treated group, and the levels of serum high-density lipoprotein cholesterol (HDL-C) were increased. Conclusion: G. elata vinegar can mitigate glucose and lipid metabolism disorders in obese mice.

Key words: Gastrodia elata vinegar; glucose and lipid metabolism; ameliorative; obesity