Abstract:

Objective: Feed on SD rats for 90 days with transferred human lactoferrin whole milk powder and their nutrition, physiological status, and biochemical indicators were investigated, thus to evaluate the influence of transferred human lactoferrin milk powder on rats serum iron and ferritin. Methods: The study refers to the People s Republic of China Agriculture Industry Standard Transgenic plants and products food safety testing (NY/T 1102—2006). A total of 140 SD rats were divided into 7 groups, including control group, transgenic low-dose group, transgenic middle-dose group, transgenic high-dose group, non-transgenic low-dose group, non-transgenic middle-dose group, and non-transgenic high-dose group. Male and female were equally distributed. The weight, feed efficiency, and blood biochemical indicators during 90 days of feeding were measured. Results: SD rats fed on transferred human lactoferrin whole milk powder for 90 days were healthy, and compared with non-transgenic group, transgenic group did not show significant difference. Transgenic milk powder can increase the serum iron and ferritin in rats noticeably, and no adverse effects were observed during the study. Conclusion: Transferred human lactoferrin whole milk powder can increase the serum iron and ferritin in rats.

Key words: Transferred human lactoferrin milk powder, serum iron, ferritin