Abstract:

Objective: To investigate the preventive effect of Atractylodes rhizome polysaccharides (AP) on chronic renal failure (CRF) rats-induced by adenine. Methods: CRF model was induced by adenine. The rats were randomized into five groups, which were designated as control group, model group, groups administered with AP at the high (APH) and low dosages (APL), and dexamethasone group. After the administration, the rats were fed in metabolism cage. The urine was collected during 12 h period without food or water. The total volume of urine, blood urine nitrogen (BUN), urine creatinine (CR), and 12-hour urine protein (12 h U-TP) were determined. Meanwhile, renal index was also evaluated. Results: Compared with the model group, BUN levels of CPL and CPH groups exhibited a significant decrease (P＜0.01 or P＜0.05). Similarly, a significant declined coefficient was also observed (P＜0.01, P＜0.05). Conclusion: AP revealed a promising preventive effect on renal failure in rats.

Key words: Atractylodes rhizome polysaccharides (AP), adenine, renal failure, rats, BUN, renal index