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ʳƷ��ѧ  2012, Vol. 33 Issue (21): 308-313    DOI:
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Effect of Lactoferrin on Th1/Th2 Cell Balance in Peripheral Blood of BALB/C Mice with Food Allergy
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Abstract�� The aim of this study was to determine the immunoregulatory effect of lactoferrin on Th1/Th2 cell balance in the peripheral blood of mice with food allergy. In order to establish allergic mouse models, BALB/C mice were repeatedly sensitized and challenged with ovalbumin. Lactoferrin was administrated to mice during preventive treatment or intragastric provocation. The levels of serum IgE, IFN-γ, IL-4, IL-6, IL-10, IL-12p40 and TGF-β were determined at 1 h after the last administration. The results showed that Th1/Th2 cell balance in the peripheral blood of mice with food allergy revealed a shift towards Th2 cell direction. Lactoferrin administration at 2 mg/(kg•d) significantly increased IFN-γ and IL-12p40 levels and IFN-γ/IL-4 ratio, but decreased IgE, IL-4 and IL-6 levels during intragastric provocation. When the dosage was increased to 20 mg/(kg•d), these cytokines except IFN-γ/IL-4 ratio were significantly decreased. Meanwhile, lactoferrin administration significantly increased the levels of serum IL-4, IL-6, IL-10, IL-12p40, IFN-γ, TGF-β and IgE during preventive treatment, especially at 20 g/(kg•d), resulting in a significant increase in IFN-γ/IL-4 ratio. Therefore, lactoferrin can promote Th1/Th2 cell balance in ovalbumin-induced food allergy mice.
Key words�� food allergy   lactoferrin   Th1/Th2 cell balance   immunoregulatory effect   
�ո�����: 2011-12-26; ��������: 2012-11-10
ͨѶ����: ��־��     E-mail: hzhihe@tjcu.edu.cn
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�ź�,��־��. �������׶�ʳ�����С������Ѫ��Th1/Th2ϸ��ƽ���Ӱ��[J]. ʳƷ��ѧ, 2012, 33(21): 308-313.
ZHANG Hao,HU Zhi-He. Effect of Lactoferrin on Th1/Th2 Cell Balance in Peripheral Blood of BALB/C Mice with Food Allergy[J]. FOOD SCIENCE, 2012, 33(21): 308-313.
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